نتایج جستجو برای: t cell inhibitor
تعداد نتایج: 2296471 فیلتر نتایج به سال:
Background Immune checkpoint inhibitor (ICI) therapies that promote T cell activation have improved outcomes for advanced malignancies yet can also elicit harmful autoimmune reactions. The mechanisms mediating these iatrogenic events remain unclear. Objectives To investigate the immunophenotype, transcriptomic feature and clonotypes of cells from joints patients affected by ICI-induced inflamma...
Background: We have shown previously that the abrogation of acute and chronic rejection of rat cardiac allografts occurs through the down-regulation of RhoA pathway and involves the changes in RhoA kinase (ROCK)-dependent actin cytoskeleton and T cell motility. Here we studied the ability of the Y-27632, a highly selective inhibitor of Rho-associated protein kinase p160ROCK (ROCK1), to abrogate...
The aim of the study was to assess expression immune checkpoint inhibitor programmed death-ligand 1 (PD-L1) in equine sarcoids (ES). Programmed is expressed by various cancer cells block T cell–mediated elimination tumor cells. Antibodies targeting human PD-L1 were tested immunohistochemistry for their cross-reactivity with using formalin-fixed, paraffin-embedded tissues. Our results do not sup...
Patients with programmed death-ligand 1 positive (PD-L1+), locally advanced or metastatic, non-squamous non-small cell lung cancer (NSCLC) have a poor prognosis and treatment options are limited. Sitravatinib, selective tyrosine kinase inhibitor, reduces the number of myeloid-derived suppressor cells regulatory T cells, promotes expansion migration antitumor cytotoxic increases ratio M1/M2-pola...
Modulation of the blood coagulation fibrinolytic system is an essential function vascular endothelial cells. Tissue plasminogen activator (t-PA) and inhibitor-1 (PAI-1) are major regulatory proteins synthesized by cells; activity dependent on balance between these proteins. Previously, we have reported that cadmium, initiator ischemic heart disease, induces PAI-1 expression suppresses in cultur...
We previously showed that the proteasome inhibitor carfilzomib and the histone deacetylase inhibitor (HDACI) vorinostat cooperated to induce cell apoptosis in one T-cell leukemia cell line in vitro, implying the possibility of the combination treatment of carfilzomib and vorinostat as a potential therapeutic strategy in human T-cell leukemia/lymphoma. Here we report that combination treatment o...
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