BACKGROUND Radioresistance is a major challenge during the treatment of NK/T cell lymphoma. This study aimed to investigate the potential role of MicroRNA-150 (miR-150) in increase the sensitivities of NK/T cell lymphoma to ionizing radiation. RESULTS In this study, we found that miR-150 was significantly decreased in NK/T cell lymphoma tissues and cell lines. Low expression of miR-150 was po...

Introduction: Mature T and NK-cell lymphomas represent a heterogeneous group of lymphoid disorders (29 subtypes according to the 2016 WHO classification) arising from mature cells post-thymic origin with different morphological characteristics, phenotypes, clinical presentation. Following success Cell Project (TCP), which allowed analysis more than 1,500 cases peripheral T-Cell (PTCLs) collecte...

Immunoblastic lymphadenopathy (lBL)-like T-cell lymphoma is a distinct peripheral T-cell lymphoma. which closely resembles angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) and/or IBL. but is characterized by focal or sheet-like proliferation of immunoblasts and pale cells of T-cell nature. In this report. 36 patients with IBI-like T-cell lymphoma were analyzed. The disease is clini...

CD20 positive T cell lymphoma is a rare condition that is associated with the coexpressions of CD20 and T cell markers, such as, CD3, CD5, or UCHL-1. Positivity for CD20 in this tumor represents an aberrant immunophenotype, but the presence of monoclonal T cell receptor (TCR) gene rearrangements and negativity for immunoglobulin heavy chain gene rearrangement indicate that this tumor is a T cel...

Current cancer diagnosis procedure requires expert knowledge and is time-consuming, which raises the need to build an accurate support system for lymphoma identification classification. Many studies have shown promising results using Machine Learning and, recently, Deep detect malignancy in cells. However, diversity complexity of morphological structure make it a challenging classification prob...

A patient with mycosis fungoides (MF), Kaposi's sarcoma, T-cell rich B-cell lymphoma, and T-cell lymphoma with angioimmunoblastic features is described. The appearance of multiple malignancies in this patient may have been caused by previous exposure to radiation in the Chernobyl accident and/or systemic chemotherapy for the initial T-cell rich B-cell lymphoma which he underwent.

Adult T cell leukemia-lymphoma is a rare disease with a high mortality rate, and is challenging for the clinician. Early allogeneic stem cell transplant can confer durable remission. As novel therapeutic agents become available to treat T cell malignancies, it is increasingly important that medical oncologists, hematologists, and hematopathologists recognize and accurately diagnose adult T cell...

MicroRNAs (miRs) play an important role in tumorogenesis and chemoresistance in lymphoid malignancies. Comparing with reactive hyperplasia, miR181a was overexpressed in 130 patients with T-cell leukemia/lymphoma, including acute T-cell lymphoblastic leukemia (n = 32), T-cell lymphoblastic lymphoma (n = 16), peripheral T-cell lymphoma, not otherwise specified (n = 45), anaplastic large cell lymp...