There are several reports suggesting that the pathophysiology of psoriasis may be associated with aberrant circadian rhythms. However, the mechanistic link between psoriasis and the circadian time-keeping system, "the circadian clock," remains unclear. This study determined whether the core circadian gene, Clock, had a regulatory role in the development of psoriasis. For this purpose, we compar...

We study a network model in which each network link is associated with a set of delays and costs. These costs are a function of the delays and reflect the prices paid in return for delay guarantees. Such a cost structure can model a setting in which the service provider provides multiple service classes with a different price and delay guarantee for each class. We are given a source node s, a s...

The dynamics of an open system crucially depends on the correlation function its environment, $C_B(t)$. We show that for thermal non-Harmonic environments $C_B(t)$ may not decay to zero but offset, $C_0>0$. presence such offset is determined by environment eigenstate structure, and whether it fulfills or thermalization hypothesis. Moreover, we a $C_0>0$ could render weak coupling approximation ...

In [3] D. Bar-Natan and S. Garoufalidis used a weight system for the Alexander polynomial of knots to prove the so-called Melvin–Morton–Rozansky conjecture [18, 21] which relates the Alexander polynomial and some coefficients of coloured Jones polynomial. Their weight system can be easily extended to the case of links. It is a natural problem to give a weight system for the multivariable Alexan...

Recent preclinical and clinical trials have demonstrated the therapeutic potential of T lymphocytes redirected with genetically engineered T-cell receptor (TCR) surrogates against infected, cancerous, or autoreactive cells. These surrogate TCRs link a ligand-recognition domain to signaling regions from the TCR. We previously compared the function of surrogate TCRs that include TCR or TCR and CD...

Now robot assisted laparoscopy has some problem to depend only on image of the surgical field. However, there is a research result which shows that it is possible to measure the operation force on commercialized instrument inside patient without sensors [1]. By using measured information, haptic technique can be implemented into surgical robot system. Therefore, this paper proposes the design o...

Gamma-aminobutyrate transaminase (GABA-T), a key homodimeric enzyme of the GABA shunt, converts the major inhibitory neurotransmitter GABA to succinic semialdehyde. We previously overexpressed, purified and characterized human brain GABA-T. To identify the structural and functional roles of the cysteinyl residue at position 321, we constructed various GABA-T mutants by site-directed mutagenesis...

1. if e is incident to a triangle t 0 6 = t 2. then (t 0 doesn't exist at the boundary of the TIN) 3. Create an edge record for the edge (z = Z) \ t 0 and link it to the vertex record created for (z = Z) \ e. 4. if t 0 has a vertex v with elevation Z 5. then create a vertex record for v and link it to the edge record for (z = Z) \ t 0 just created. 6. Find-Component-From-Vertex(t 0 ; v) 7. else...

Generalized linear mixed models (GLMM) are commonly used to analyze hierarchical data. Unlike linear mixed models, they do not automatically provide parametric marginal regression functions, while such functions are needed for population-averaged inferences. This issue has received considerable attention and here three approaches to address it are reviewed, expanded, and compared: (1) the close...