▼ Objective: To investigate intracerebral insulin resistance and its relationship with tau-protein hyperphosphorylation. Methods: A rat model of type 2 diabetes (T2D) was established with streptozotocin (STZ). Diabetic rats received intragastric administration of pioglitazone (PIO group) or normal saline (T2D group) for 4 weeks. As a control, non-diabetic rats received intragastric normal salin...

Type 2 diabetes (T2D) is associated with accelerated restenosis rates after angioplasty. We have previously proved that Pin1 played an important role in vascular smooth muscle cell (VSMC) cycle and apoptosis. But neither the role of Pin1 in restenosis by T2D, nor the molecular mechanism of Pin1 in these processes has been elucidated. A mouse model of T2D was generated by the combination of high...

This study aimed to examine genomic loci of type 2 diabetes (T2D) initially identified by genome-wide association studies in populations of European ancestry for their associations with T2D and quantitative glycemic traits, as well as their effects on longitudinal change in fasting plasma glucose (FPG) and T2D development, in the Chinese population. Single nucleotide polymorphisms (SNP) from 25...

BACKGROUND There is emerging evidence linking diabetes with periodontal disease. Diabetes is a well-recognized risk factor for periodontal disease. Conversely, pro-inflammatory molecules released by periodontally-diseased tissues may enter the circulation to induce insulin resistance. While this association has been demonstrated in adults, there is little information regarding periodontal statu...

▼ Objective: To investigate intracerebral insulin resistance and its relationship with tau-protein hyperphosphorylation. Methods: A rat model of type 2 diabetes (T2D) was established with streptozotocin (STZ). Diabetic rats received intragastric administration of pioglitazone (PIO group) or normal saline (T2D group) for 4 weeks. As a control, non-diabetic rats received intragastric normal salin...

Increased endothelin-1 (ET-1) and reduced endothelial nitric oxide phosphorylation (peNOS) are hypothesized to reduce insulin-stimulated blood flow in type 2 diabetes (T2D), but studies examining these links in humans are limited. We sought to assess basal and insulin-stimulated endothelial signaling proteins (ET-1 and peNOS) in skeletal muscle from T2D patients. Ten obese T2D [glucose disposal...

Background: Protein intake has been associated with the development of pre-diabetes (pre-T2D) and type 2 diabetes (T2D). The gut microbiota capacity to produce harmful metabolites derived from dietary protein. Furthermore, both composition metabolic status (e.g., insulin resistance) can be modulated by diet ethnicity. However, date most studies have predominantly focused on carbohydrate fiber r...

There is increasing interest in the role of nitric oxide (NO) in common metabolic disorders such as type 2 diabetes (T2D) however, fiber-type specific changes in NO synthase (NOS) expression in skeletal muscle of T2D patients remain to be elucidated. Here we investigated fiber-type related NOS expression in the Vastus lateralis muscle of T2D patients compared with healthy individuals with norma...

The past two decades have seen an explosive increase in the number of people diagnosed with diabetes mellitus worldwide, particularly type 2 diabetes (T2D), which is found associated with modern lifestyle, abundant nutrient supply, reduced physical activity, and obesity. Actually, between 60 and 90% of cases of T2D now appear to be related to obesity. Numerous studies have shown that insulin re...

BACKGROUND To support a hypothesis that there is an intrinsic interplay between coronary artery disease (CAD) and type 2 diabetes (T2D), we used RNA-seq to identify unique gene expression signatures of CAD, T2D, and coexisting conditions. METHODS After transcriptome sequencing, differential expression analysis was performed between each disordered state and normal control group. By comparing ...