Tissue specificities in inhibitory action of excess triiodothyronine (T3) on creatine uptake from the plasma and the effect of denervation of the muscle on the inhibitory action were studied in rats with the use of radioactive creatine. The uptake of radioactive creatine of all muscles studied significantly diminished after T3 (100 microgram/100 g, s.c.) injection, while that of brain was not a...

Effects of triiodothyronine (T3) on the expression of cytoskeletal and myofibrillar proteins in adult rat cardiomyocytes (ARC) were followed during two weeks of culture in the presence of 20% T3-depleted (stripped) FCS. Control cultures expressed mainly b -myosin heavy chain (MHC) mRNA. T3 caused a switch to a -MHC expression and a dose-dependent increase of a -smooth muscle ( a -sm) actin mRNA...

The physiological and developmental effects of thyroid hormones are mainly due to the control of gene expression after interaction of T3 with the nuclear receptors. To understand the role of thyroid hormones on cerebral cortex development, knowledge of the genes regulated by T3 during specific stages of development is required. In our laboratory, we previously identified genes regulated by T3 i...

The effect of isoflurane (Forane) anaesthesia and surgery on thyroid function was investigated in nine male patients. Isoflurane anaesthesia alone for 30 minutes prior to the start of surgery increased plasma triiodothyronine uptake (T3U) and thyroxine (T4) level by 18 and 20 per cent, respectively. Free thyroxine index (FTI) values in blood increased by 62 per cent during the same period. One ...

BACKGROUND: Many patients using warfarin may be at risk of international normalized ratio fluctuations. This may cause severe massive gastrointestinal or cerebral bleeding. Subclinical hypothyroidism in our population is highly prevalent (range from 3.1% to 8.4% for males and females respectively). Overt hypothyroidism diminishes the effect of warfarin but there is a lack of results on the effe...

Market-size (61-68 day-old) AA broiler chickens were exposed to simulated high-cyclic summer temperatures of North, Central and South China for 5 continuous days. Blood samples were collected at 0AM, 4AM, 8AM, 0PM, 4PM and 8PM each day, and concentrations of triiodothyronine (T3) and thyroxine (T4) were determined by double-antibody radioimmunoassay (RIA). T3, T4 concentration and T3/T4 ratio h...

A semiautomatic procedure is presented for the separate determination of total T3 and T4 in serum in approximately 10 hrs simultaneously in 25 samples. Removal of the thyroid hormones from the serum, separation of T3 from T4 and concentration of the peaks were achieved in a closed system, consisting of three consecutive columns. The automatic microchemical iodine determination of T3 and T4 resp...

Mucus hypersecretion is a distinguished feature of chronic inflammatory airway diseases. Interestingly, in this condition thyroid function is impaired with decreased level of triiodothyronine (T3), indicating potential link between low level of T3 and mucus hypersecretion. But the underlying mechanisms are poorly understood. In this study we aimed to elucidate the effect of T3 on MUC5AC secreti...