In pharmaceutical manufacturing, the utmost aim is reliably producing high quality products. Simulation approaches allow virtual experiments of processes in planning phase and implementation digital twins operation. The industrial processing active ingredients (APIs) into tablets requires combination discrete continuous sub-processes with complex interdependencies regarding material structures ...

D. R. Serrano Lopez, P. O'Connell, A. M. Healy Trinity College Dublin Purpose Sulfadimide (SDM) is a poorly-soluble anti-infective agent. Co-crystallization with suitable coformers, such as 4aminosalicylic acid (4ASA), combined with changes in the crystal habit, can favourably alter its physicochemical properties. The aim was to engineer SDM: 4ASA cocrystals with different habits and investigat...

The study was carried out to investigate the drug release profiles of multi-unit dosage formulations of theophylline consisting of both the fast and slow release components in a unit dose. The fast release component consisted of conventional granules of theophylline formed by mixing the drug powder with starch mucilage (20% w/v) while the slow release component consisted of wax granulations of ...