STUDY OBJECTIVES The objective of this study was to evaluate the feasibility of the sentinel lymph node (SLN) biopsy in peripheral clinically stage I or II non-small cell lung cancer (NSCLC) using (99m)Tc colloid and a hand-held gamma detection probe, associated with a blue dye technique. DESIGN Prospective study. SETTING Royal Brompton Hospital, London, UK; and Hopital Nord, Saint Etienne,...

Forty-eight patients with ;cold areas' on (99m)Tc sulphur colloid liver scintiscans were scanned again using (75)Se-selenomethionine. In 11 patients with primary hepatocellular carcinoma considerable uptake of (75)Se-selenomethionine could be demonstrated in the area of the tumour and uptake of (75)Se-selenomethionine was also observed over extrahepatic metastases in two of these cases. In cont...

Technetium-99m-antimony trisulfide colloid ((99m)Tc-ATC) was investigated with varying specific activity in the rat lymphatic system, as well as its binding to rat blood cells in vitro. Low, moderate and high doses of (99m)Tc-ATC were subdermally injected into tails of rats (n=3) and 30min later whole body lymphoscintigraphic images were acquired. (99m)Tc-ATC was incubated for 30min at 37°C wit...

A 61-year-old man presented with aggressive hepatitis. Howell-Jolly bodies were present in circulating erythrocytes and the spleen failed to accumulate intravenously administered Tc-99 m sulfur colloid. The patient thus demonstrated functional asplenia. He was treated with high doses of steroids. Four years later, Howell-Jolly bodies were no longer present in circulating erythrocytes. In additi...

The clinical consequences of lower gastrointestinal bleeding range from trivial to life-threatening. Nuclear medicine imaging techniques allow identification of those patients who are actively bleeding. The demonstration of active bleeding not only provides important prognostic information but also allows for a coordinated imaging approach using angiography and aids localization of the bleeding...

Biomarkers providing in vivo quantification of the basic elements of cystic fibrosis (CF) lung disease are needed. A study was performed to determine whether the absorption of a small radiolabelled hydrophilic molecule (Indium-111 (In-)DTPA) would be increased in CF airways. DTPA clearance has been used previously to assess epithelial permeability and may also be useful for quantifying liquid a...

The presence of hypersplenism and or respond to intravenous particulate functional asplenia occurring concomiantigen, retains the splenic reservoir tantly in a child with sickle cell anemia function to pool platelets. This reserprompted a study of the splenic platevoir function is lost in the older patient let reservoir in this hemoglobinopathy. in whom the spleen has become autoThe young child...