نتایج جستجو برای: tcep
تعداد نتایج: 132 فیلتر نتایج به سال:
The conserved TPLH tetrapeptide motif of ankyrin repeats (ARs) plays an important role in stabilizing AR proteins, and histidine (TPLH) to arginine (TPLR) mutations in this motif have been associated with a hereditary human anemia, spherocytosis (HS). Here, we used a combination of Atomic Force Microscopy (AFM)-based single-molecule force spectroscopy and molecular dynamics (MD) simulations to ...
Open AccessCCS ChemistryRESEARCH ARTICLE23 Feb 2021Elucidating the Molecular Mechanism of Dynamic Photodamage Photosystem II Membrane Protein Complex by Integrated Proteomics Strategy Ye Zhou, Zheyi Liu, Mingdong Yao, Jun Chen, Yanan Xiao, Guangye Han, Jian-Ren Shen and Fangjun Wang Zhou CAS Key Laboratory Separation Sciences for Analytical Chemistry, Dalian Institute Chemical Physics, Chinese ...
•The RNA ligase RTCB is susceptible to copper-dependent oxidative inactivation•The flavoprotein PYROXD1 uses NAD(P)+ safeguard mammalian against oxidation•Depletion of impairs pre-tRNA splicing and the unfolded protein response•Myopathy-causing genetic variants fail preserve activity The tRNA complex (tRNA-LC) splices precursor tRNAs (pre-tRNA), Xbp1-mRNA during response (UPR). In aerobic condi...
•Morphological profiling can identify bioactive compounds and suggest putative targets•Thermal proteome of small molecules usually identifies multiple targets•Targets be prioritized by combining morphological thermal profiling•Thereby, a σ1 receptor antagonist was discovered Phenotypic screening for is typically combined with affinity-based chemical proteomics to uncover the respective molecula...
Open AccessCCS ChemistryCOMMUNICATION1 Mar 2021Logic-Gated Plasmonic Nanodevices Based on DNA-Templated Assembly Fengsong Liu†, Qiao Jiang†, Qing Liu, Na Li, Zihong Han, Chao Zhaoran Wang, Yunfei Jiao, Jiashu Sun and Baoquan Ding Liu† CAS Key Laboratory of Nanosystem Hierarchical Fabrication, Center for Excellence in Nanoscience, National Nanoscience Technology, Beijing 100190 University Chines...
Nascent Polypeptide-associated Complex (NAC) was identified in eukaryotes as the first cytosolic factor which contacts the nascent polypeptide chain emerging from the ribosome. NAC is present as a homodimer in Archaea and as a highly conserved heterodimer in eukaryotes. Mutations in NAC cause severe embryonically lethal phenotypes in mice, D. melanogaster and C. elegans. In the yeast Saccharomy...
Amylomaltase MalQ is essential for the metabolism of maltose and maltodextrins in Escherichia coli. It catalyzes transglycosylation/disproportionation reactions in which glycosyl or dextrinyl units are transferred among linear maltodextrins of various lengths. To elucidate the molecular basis of transglycosylation by MalQ, we have determined three crystal structures of this enzyme, i.e. the apo...
Human defensin 5 (HD5) is a 32-residue host-defense peptide expressed in the gastrointestinal, reproductive, and urinary tracts that has antimicrobial activity. It exhibits six cysteine residues that are regiospecifically oxidized to form three disulfide bonds (Cys3—Cys31, Cys5—Cys20, and Cys10—Cys30) in the oxidized form (HD5ox). To probe the solution structure and oligomerization properties o...
Activation of the inositol-requiring enzyme-1 alpha (IRE1a) protein caused by endoplasmic reticulum stress results in the homodimerization of the N-terminal endoplasmic reticulum luminal domains, autophosphorylation of the cytoplasmic kinase domains, and conformational changes to the cytoplasmic endoribonuclease (RNase) domains, which render them functional and can lead to the splicing of X-box...
Adherence of bacteria to biotic or abiotic surfaces is a prerequisite for host colonization and represents an important step in microbial pathogenicity. This attachment is facilitated by bacterial adhesins at the cell surface. Due to their size and often elaborate multi-domain architectures, these polypeptides represent challenging targets for detailed structural and functional characterization...
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