The attrition of telomeres is believed to be a key event not only in mammalian aging, but also in disturbed nutrient sensing, which could lead to numerous metabolic dysfunctions. The current debate focuses mainly on the question whether telomere shortening, e.g., as a heritable trait, may act as a cause or rather represents a consequence of such chronic diseases. This review discusses the damag...

Hematopoietic reconstitution after stem cell transplantation requires excessive replicative activity because of the limited number of stem cells that are used for transplantation. Telomere shortening has been detected in hematopoietic cells after bone marrow transplantation. This has been thought to result from excessive replication of the stem cells, with putative concomitant reduction of thei...

BACKGROUND Increased cell turnover in response to injury is considered to be important in the development of atherosclerotic plaques. Telomere shortening has been shown to be associated with cell turnover. We assessed the telomere length of human coronary endothelial cells to clarify whether there is a relationship between telomere shortening and coronary artery disease (CAD). METHODS AND RES...

PURPOSE Although intestinal metaplasia is often found in association with adenocarcinoma of the urinary bladder, it is unclear whether intestinal metaplasia of the bladder is a premalignant lesion. Telomere shortening has recently been implicated in epithelial carcinogenesis. We used quantitative fluorescent in situ hybridization (FISH) to measure telomere length and UroVysion FISH to detect cy...

Exposure to air pollution during the first 1000 days of life (from conception 2nd year life) might be particular relevance for long-term child health. Changes in molecular markers such as DNA methylation and telomere length could underlie association between exposure pollution-related diseases well serve biomarkers past exposure. The objective this systematic review was assess pregnancy two yea...

Normal human cells undergo a finite number of cell divisions and ultimately enter a nondividing state called replicative senescence. It has been proposed that telomere shortening is the molecular clock that triggers senescence. To test this hypothesis, two telomerase-negative normal human cell types, retinal pigment epithelial cells and foreskin fibroblasts, were transfected with vectors encodi...

Telomeres are progressively eroded during repeated rounds of cell division due to the end replication problem but also undergo additional more substantial stochastic shortening events. In most cases, shortened telomeres induce a cell-cycle arrest or trigger apoptosis, although for those cells that bypass such signals during tumour progression, a critical length threshold is reached at which tel...

The incidence of diabetes is predicted to increase to 21% by 2050. Currently, one third of US adults are obese and over 11% of these individuals have diabetes. Due to the growing need for therapeutic intervention to control and/or stabilize this increase in the incidence of diabetes in Western communities, gaining a comprehensive understanding of the association between obesity and Type 2 diabe...

indirect because these complications may induce a massive expansion of lymphocytes with a subsequent impact on the average size of the telomeres in the patient’s leukocytes. In conclusion, we think it unlikely that the telomere shortening observed after allogeneic SCT is substantial enough to cause replicative exhaustion that would lead to subsequent complications. Importantly, correlations bet...

Introduction: Telomeres are repetitive sequences of TTAGGG section that find at two ends of eukaryotic chromosomes and they shield chromosome ends. Telomere shortening in patients with myocardial infarction has been reported. Shelterin complex's role is essential in telomere length regulation. Telomeric repeat binding factors 1 and 2 (TRF1 and TRF2) are the most important sheltrein complex pr...