AIMS This study was carried out to assess the protective and anti-oxidant activities of the methanolic extract of Tribulus terrestris fruits (METT) against sodium valproate (SVP)-induced testicular toxicity in rats. MATERIALS AND METHODS Fifty mature male rats were randomly divided into five equal groups (n = 10). Group 1 was used normal (negative) control, and the other four groups were into...

In previous studies, we established that kolaviron (KV) (a biflavonoid from Garcinia kola seeds) elicited anti-oxidative and hepatoprotective effects in Wistar rats chronically treated with ethanol. The present study investigates the possible ameliorative effect of KV against ethanol-induced reproductive toxicity in male Wistar rats. Twenty-eight rats were randomly divided into four groups of s...

P-Nitrophenol (PNP) is considered to be one of nitrophenol derivatives of diesel exhaust particles. PNP is a major metabolite of some organophosphorus compounds. PNP is a persistent organic pollutant as well as one of endocrine-disrupting compounds. Consequently, bioaccumulation of PNP potentiates toxicity. The objectives of the current study were to assess in vivo adverse effects of long-term ...

oxidative stress is one of the important causes of the type 1 diabetes induced changes in the sperm quality. bioflavonoids, rutin 10 mg/kg and naringin 10 mg/kg were evaluated for their protective effects on sperm parameters, oxidative stress, and histopathology of type 1 diabetic rats. results demonstrated the reduction in sperm count, sperm motility and vitality in diabetic rats. mass drug ad...

conclusions preoperative diagnosis of spermatic cord leiomyosarcma is difficult and commonly made by histological examination and immunochemical staining. case presentation here we reported a 75-year-old man who presented with a painless lump in the right hemiscrotum. a right radical orchiectomy was performed. histopathology confirmed a neoplastic tissue with mesenchymal origin in spermatic cor...

Oxidative stress is one of the important causes of the type 1 diabetes induced changes in the sperm quality. Bioflavonoids, Rutin 10 mg/Kg and Naringin 10 mg/Kg were evaluated for their protective effects on sperm parameters, oxidative stress, and histopathology of type 1 diabetic rats. Results demonstrated the reduction in sperm count, sperm motility and vitality in diabetic rats. Mass drug ad...

The importance of glucose is well known as an energy source in testes. In order to evaluate the effects long-lasting hypoglycemia on testes, a novel glucokinase activator, TMG-123, was dosed rats at 5, 20 and 100 mg/kg for 13 weeks. As result, plasma levels decreased several hours with increasing doses over dose range 5 mg/kg. No toxicological findings attributable test article were observed cl...

Polystyrene nanoplastics (NP) are often found in aquatic environments. The accumulation of biota such as fish, shrimp, squid, shellfish, etc. can reduce the health humans who consume them. purpose this study was to observe red seaweed’s potential a source antioxidants improving immune system and reproductive rats (Rattus novergicus) exposed nanoplastics. Twenty-five norvegicus) were divided int...


 This study evaluated the effect of gossypol acetate, a potential antifertility compound, on semen quality and testicular histopathology boars. Six boars were allotted into two experimental groups. Half animals fed diet that was supplemented with 2 mg acetate per kg body weight day for 9 weeks, control received acetate-free feed. During period, collected weekly from each boar parameters r...