In 4 Phase III registration trials (3 in patients with partial seizures, N=1480; 1 in patients with PGTCS, N=163), perampanel administered to patients already receiving 1-3 concomitant antiepileptic drugs (AEDs) demonstrated statistically superior efficacy compared to placebo in reducing seizure frequency. However, use of perampanel in these studies was associated with a risk of psychiatric and...

The goal of the current study is to clarify the relationship between social information processing (e.g., visual attention to cues of hostility, hostility attribution bias, and facial expression emotion labeling) and aggressive tendencies. Thirty adults were recruited in the eye-tracking study that measured various components in social information processing. Baseline aggressive tendencies were...

OBJECTIVE The aim of the present study was to find out the extent of hostility and violence and the factors that are associated with such hostility and violence in a psychiatric intensive care unit. METHODS Retrospective analysis of data prospectively collected in a 6-year period. RESULTS No hostility was observed in 56.1%, hostility in 40.9%, and violence in 3.0% of the admitted cases. Sec...

OBJECTIVE The current study examined the relation of anger, hostility, and severity of depressive symptoms, alone and in combination, to C-reactive protein (CRP) in healthy men and women. METHODS A high sensitivity enzyme linked immuno sorbent assay (ELISA) was used to evaluate CRP levels in a multiethnic sample of 127 healthy, nonsmoking men and women. Fasting blood samples were collected th...

OBJECTIVE Previous research has produced mixed results pertaining to the association between hostility and insulin resistance. These inconsistent findings may be the result of a lack of studies examining potential moderators of this relationship and inconsistent measures of insulin resistance and/or hostility. We hypothesized that hostility may interact with circulating norepinephrine (NEPI) le...

Introduction: Since the significant impact on anger and hostility is caused by posttraumatic stress disorder (PTSD) on various aspects of individual, family, social, and vocational life of those who suffer from this disorder, it is necessary to target and cure these two devastating symptoms.The aim of this study was to determine the effectiveness of Schema therapy in decrease anger and hostilit...