Antimicrobial screening of several novel 4-thiazolidinones with benzothiazole moiety has been performed. These compounds were evaluated for antimicrobial activity against a panel of bacterial and fungal strains. The strains were treated with these benzothiazole derivatives at varying concentrations, and MIC's were calculated. Structures of these compounds have been determined by spectroscopic s...

In this study, a novel series of 4-thiazolidinone derivatives (1-17) was synthesized and evaluated for its in vitro antimicrobial and anticancer potentials. N-(2-(5-(4-nitrobenzylidene)-2-(4-chlorophenyl)-4-oxothia- zolidin-3-ylamino)-2-oxoethyl) benzamide (7, pMICam = 1.86 µM/mL) was found to be the most active antimi- crobial agent. The anticancer study results demonstrated that N-(2-(5-(4-hy...

A rapid and efficient one pot solvent/scavenger-free protocol for the synthesis of 2-iminothiazolidin-4-ones has been developed. Interestingly, the regio/stereoselective synthesis affords the regioisomeric (Z)-3-alkyl/aryl-2-(2-phenylcyclohex-2-enylimino)thiazolidin-4-one as the sole product in good yield. The selectivities observed have been rationalized based on the relative magnitude of the ...

On account of the reported anticancer activity of pyrazoles and thiazolidin-4-ones, we have designed and synthesized a series of novel 3-phenyl-2-(3-aryl-1-phenyl-1H-pyrazol-4-yl)thiazolidin-4-ones and investigated their COX-1 and COX2 inhibition potential and also their in vitro cytotoxic activity by MTT assay. Amongst the tested compounds, the compound 3e was found to be most potent COX-2 inh...

The first report about antimicrobial resistance was published in the 1940s. And today, has become a worldwide problem. Because of this problem, there is need to develop new drugs. That’s why we synthesized some novel thiazolidine-4-one derivatives and evaluated their activity. final compounds were obtained by reacting 2-[(4,5-diphenylthiazol-2-yl)imino]thiazolidin-4-one with aryl aldehydes. inv...

In search for new leads towards potent anti-inflammatory agents, an array of 5-methoxy-3-(3’-chloro-2’oxo-4-substitutedaryl-1’-azetidinyl)indoles (4a-4e) and 5-methoxy-3-(2’-substitutedaryl-4’-oxo-1’,3’-thiazolidin-3’-yl)indoles (5a-5e) have been synthesized form 5-methoxy-3-substitutedbenzylidenlaminoindoles (3a-3e). Structure of all the synthesized compounds has been analyzed using elemental ...