نتایج جستجو برای: thiotepa

تعداد نتایج: 617  

2006
Richard L. Heideman Diane E. Cole Frank Balis Judy Sato Gregory H. Reaman Roger J. Packer Lawrence J. Singher Lawrence J. Ettinger Andrea Gillespie Joseph Sam David G. Poplack

A Phase I trial of thiotepa (II) administered as an i.v. bolus was performed in 19 children with refractory malignancies. The starting dose was 25 mg/m2 with escalations to 50, 65, and 75 mg/nr. Seven additional patients were treated with 8-h infusions at 50 or 65 mg/m2. The maximum tolerated bolus dose was 65 mg/m2. Reversible myelosuppression was the dose-limiting toxicity. The plasma and cer...

Journal: :Cancer research 1989
R L Heideman D E Cole F Balis J Sato G H Reaman R J Packer L J Singher L J Ettinger A Gillespie J Sam

A Phase I trial of thiotepa (TT) administered as an i.v. bolus was performed in 19 children with refractory malignancies. The starting dose was 25 mg/m2 with escalations to 50, 65, and 75 mg/m2. Seven additional patients were treated with 8-h infusions at 50 or 65 mg/m2. The maximum tolerated bolus dose was 65 mg/m2. Reversible myelosuppression was the dose-limiting toxicity. The plasma and cer...

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