Lehmann et al.1 pointed out that taken together, the large cardiac resynchronization therapy (CRT) trials included 10,803 patients, the majority of who were in congestive heart failure (CHF) New York Heart Association (NYHA) class III, but only 451 patients (4.2%) were class IV. The role of CRT in NYHA class IV patients remained uncertain until recently when Lindenfeld et al.2 reported the resu...

BACKGROUND/PURPOSE Kasai portoenterostomy is recommended as the primary initial therapy for extrahepatic biliary atresia if the procedure can be performed within 10 to 12 weeks of life. The optimal management for infants with delayed presentation of biliary atresia remains controversial. The purpose of this study was to determine the success rate and outcome for patients who underwent a "late" ...

Over the past 15 years, there has been an increase in youth sports participation with a concomitant increase in early year-round training in a single sport. Many factors contribute to the desire of parents and coaches to encourage early single sport specialization, including the desire to give the young athlete an edge in competition, pursuit of scholarships, and potential professional status, ...

AIMS This paper aims to describe the contextual factors that gave rise to evidence-based medicine (EBM), as well as its controversies and limitations in the current health context. Our analysis utilizes two frameworks: (1) a complex adaptive view of health that sees both health and healthcare as non-linear phenomena emerging from their different components; and (2) the unified approach to the p...

(AS) is currently the most common cause of AS in adults and the most frequent reason for aortic valve replacement (AVR) in these patients. Its incidence is on the rise since this pathology is a disease of ageing and the population is getting older.1 The natural history of AS has shown that in the absence of surgical management the patient develops progressive invalidating symptoms of syncope an...

The advent of novel focal therapies theoretically opens up new treatment avenues for patients with localised prostate cancer (PCa). Presently, management is dichotomised between active surveillance and radical, whole-gland therapy, such as prostatectomy and radiotherapy. While the former burdens patients with the detrimental diagnosis of cancer without the reassurance of treatment, the latter i...

he phrase “location, location, location” has been Tused in the real estate business for more than 90 years to convey the overriding importance of location in determining value, function, and opportunity. It now may be important in how we approach pancreatitis. Pancreatitis is a painful and often debilitating disease for which there are no specific or effective treatments. Although patient morta...