objective: druggability of a target protein depends on the interacting micro-environment between the target protein and drugs. therefore, a precise knowledge of the interacting micro-environment between the target protein and drugs is requisite for drug discovery process. to understand such micro-environment, we performed in silico interaction analysis between a human target protein, dipeptidyl...

The design, fabrication and performance of a novel and highly sensitive micro-reactor device for performing in situ grazing-incidence X-ray scattering experiments of model catalyst systems is presented. The design of the reaction chamber, etched in silicon on insulator (SIO), permits grazing-incidence small-angle X-ray scattering (GISAXS) in transmission through 10 µm-thick entrance and exit wi...

Microelectromechanical Systems (MEMS) is the technology of the very small, and merges at the nano-scale into "Nanoelectromechanical" Systems (NEMS) and Nanotechnology. MEMS are also referred to as micro machines, or Micro Systems Technology (MST). MEMS are separate and distinct from the hypothetical vision of Molecular nanotechnology or Molecular Electronics. MEMS generally range in size from a...

Recent advances in MEMS fabrication technology have resulted in a proliferation of microscale mechanical devices, some of which are applied in environments with severe levels of shock. The objective of this paper is to investigate the use of experimental and simulation methods in quantifying the behaviour of representative MEMS devices subject to high-g impact stimuli. Representative micro-cant...

INTRODUCTION: Conventional techniques used to image microdamage in cortical bone require the preparation of many histologic sections which is inherently invasive, destructive, two-dimensional, and tedious [1]. These limitations inhibit evaluation of the effects of microdamage on whole bone strength and prohibit detection of microdamage in vivo. Therefore, micro-computed tomography (micro-CT) ha...

OBJECTIVE Monomer development for a reduced shrinkage of composite materials still challenges the modern research. The purpose of this study was to analyse the shrinkage behavior of an innovative composite material for dental restorations based on a resin system that is claimed to control polymerization kinetics having incorporated a photoactive group within the resin. METHODS Shrinkage stres...