Even the life span has prolonged for the last 40 years, increase in frequently seen complications with increasing age negatively affect the life quality of thalassemia patients. In our study, complications encountered in 67 ß-thalassemia patients who were followedup at our hospital between 1 January 2004 and 31 May 2009 were retrospectively analyzed. Fifty-six patients were followed up with dia...

The number of people with type 2 diabetes mellitus (T2DM) has been increasing worldwide [1]. The majority of patients with long-term course of diabetes mellitus (DM) (mainly T2DM) are diagnosed with cardiovascular diseases. Conditionally, there are two main forms of heart disease in case of DM: diabetic cardiomyopathy and ischemic heart disease (IHD). There is a metabolic stage (actual cardiomy...

essential thrombocythemia is a chronic myeloproliferative disorder characterized by a sustained proliferation of megakaryocytes, which leads to increased numbers of circulating platelets. hemorrhagic and/or thrombotic episodes are frequent, and thrombosis of both veins and arteries may develop. vessels in unusual sites may be involved, e.g., the hepatic veins, mesenteric veins, and the digital ...

There is nervous control of the heart by ATP as a cotransmitter in sympathetic, parasympathetic, and sensory-motor nerves, as well as in intracardiac neurons. Centers in the brain control heart activities and vagal cardiovascular reflexes involve purines. Adenine nucleotides and nucleosides act on purinoceptors on cardiomyocytes, AV and SA nodes, cardiac fibroblasts, and coronary blood vessels....

Plasminogen activator inhibitor type 1 (PAI-1) is a proteinase inhibitor1 constituting the key regulator2 of the activity of the fibrinolytic system, an important protective mechanism against thrombosis. Because a reduced fibrinolytic activity, mainly caused by increased plasma levels of PAI-1, was a common finding in cross-sectional studies of patients with coronary artery disease (CAD),3 high...

Friedreich’s ataxia (FRDA) is a form of neuropathy that was fi rst described by Nikolaus Friedreich in a series of 5 papers published from 1863-1877 (1). Freidreich was a third generation physician from Heidelberg, Germany. His grandfather was the fi rst to describe idiopathic facial paralysis, also known as Bell’s palsy. Friedreich trained to be a pathologist under Rudolf Virchow, who proposed...

The number of people with type 2 diabetes mellitus (T2DM) has been increasing worldwide [1]. The majority of patients with long-term course of diabetes mellitus (DM) (mainly T2DM) are diagnosed with cardiovascular diseases. Conditionally, there are two main forms of heart disease in case of DM: diabetic cardiomyopathy and ischemic heart disease (IHD). There is a metabolic stage (actual cardiomy...

The common cause of sudden cardiac death is ischaemic heart disease. Such patients may have an occlusive recent thrombosis in a major coronary artery but the largest group has no recent occlusion. Comparison of such patients without occlusion with non-cardiac death control hearts suggests that an area of stenosis of 85 per cent is the best discriminating level. Most subjects who die of ischaemi...

We are describing briefly another family with cardiomyopathy, where a woman and three of her four children were affected. Some of them have been under observation for twelve years and have been examined by the three authors at different periods. The mother had been suspected for many years of having some form of congenital heart disease because of a murmur. She and her three affected children w...

the aim of the study was to evaluate the clinical usefulness of n-terminal pro-brain natriuretic peptide (nt-pro bnp) and nitric oxide (no) with echocardiography (gold standard test) in diagnosis of canine cardiomyopathy. out of 374 cases, 82 cases showing cardiovascular abnormalities including 16 cases of cardiomyopathy were further selected for standardization of biomarkers. significant (p