In 1901, Weigert described a patient with myasthenia gravis, thymoma, and lymphorrhages. He regarded these lymphocellular infiltrates in the muscles as metastases of the thymoma. Lymphorrhages have since been frequently described in patients with myasthenia, with or without thymoma (Link, 1903; Rowland, Hoefer, Aranow, and Houston Merritt, 1956; Mendelow, 1958; Genkins, Mendelow, Sobel, and Oss...

Thymoma is a rare tumor that commonly associated with autoimmune diseases. Of these, myasthenia gravis (MG) widely considered as the most common paraneoplastic condition. On other hand, dermatomyositis (DM) has been rarely reported first presentation of non-invasive thymoma. Hereby, we describe patient thymoma who initially presented painful symmetric proximal muscle weakness no signs ptosis or...

Myasthenia gravis (MG) is an autoimmune neuromuscular disease leading to fluctuating muscle weakness. Approximately 70% of patients with MG have thymic hyperplasia, and 10–20% of them have thymoma. In MG patients without thymoma, thymectomy should be performed only in selected patients. In contrast, thymectomy should be performed in all patients with thymoma. In addition, thoracoscopic thymecto...

Objective Although 18-fluorine fluorodeoxyglucose positron emission tomography (18F-FDG PET) is thought to be useful for predicting the histological grade of thymic epithelial tumors (TETs), it remains controversial. To date, just a few of many previous studies have included only resected cases. Therefore, we investigated 18F-FDG PET findings only in patients with resected TETs. Patients and ...

Thymomas, with their diverse signs, symptoms and relationships to other systemic diseases, are not infrequently encountered. Histologic classification is now standardized. Thymoma is associated with other disorders, such as myasthenia gravis and pure red cell aplasia. Proper staging, careful histologic evaluation and appropriately selected therapy are necessary to ensure long-term survival.

PURPOSE The purpose of this study is to assess the clinicopathologic features, treatment outcomes, and role of adjuvant radiation therapy (RT) in cervical thymic neoplasm involving the thyroid gland or neck. MATERIALS AND METHODS The medical and pathologic records of eight patients with cervical thymic neoplasm were reviewed retrospectively. All patients underwent surgical resection, includin...

INTRODUCTION Type AB thymoma is generally considered a benign tumor with excellent prognosis. Rare case reports of type A and AB thymomas with recurrence and metastasis have been documented, although extrathoracic metastases are extremely rare. To the best of our knowledge, this is the first reported case of type AB thymoma with solitary metastasis to the breast. CASE PRESENTATION We describe...

To the Editor: “Good syndrome” is defined as the combination of thymoma, hypogammaglobulinemia, low numbers of peripheral B cells and variable defects in cell-mediated immunity with a CD4 T lymphopenia and an inverted CD4/ CD8+ T-cell ratio [1]. Although thymomas associated with “Good syndrome” are mostly benign, this humoral immunodeficiency may be associated with high risk of metastatic sprea...

Thymoma is a rare tumor with a largely indolent growth pattern. It does, however, have malignant potential as a result of its ability to invade locally and metastasize regionally. Often associated with a number of immune- and nonimmune-mediated paraneoplastic syndromes, patient outcomes are directly related to stage of disease and the ability to achieve a complete surgical resection. Surgery is...

We report on a case of a 57 years-old white male, patient, who presented superior vena cava syndrome (SVC) for 3 months, derived from an invasive thymoma in the medium and anterior mediastinum, compromising intrinsic and extrinsic to the SVC. After evaluation by computed tomography and magnetic angioresonance of the thorax, the patient underwent radical resection of the thymoma--bypass from lef...