Here, we analyze the complete coding sequences of all recognized tick-borne flavivirus species, including Gadgets Gully, Royal Farm and Karshi virus, seabird-associated flaviviruses, Kadam virus and previously uncharacterized isolates of Kyasanur Forest disease virus and Omsk hemorrhagic fever virus. Significant taxonomic improvements are proposed, e.g. the identification of three major groups ...

Abstract Spirochetes of the family Borreliaceae are, with one exception, tick-borne pathogens a variety vertebrates. The at present comprises two genera: Borrelia (Swellengrebel), which includes agents relapsing fever, avian spirochetosis, and bovine borreliosis, Borreliella (Gupta et al.), Lyme disease was formerly known as ‘Borrelia burgdorferi sensulato complex’. genera are distinguished not...

Several important human diseases worldwide are caused by tick-borne viruses. These diseases have become important public health concerns in recent years. The tick-borne viruses that cause diseases in humans mainly belong to 3 families: Bunyaviridae, Flaviviridae, and Reoviridae. In this review, we focus on therapeutic approaches for several of the more important tick-borne viruses from these 3 ...

Isolates of Borrelia turicatae, Borrelia parkeri, and the Florida canine borrelia (FCB) were examined to further phylogenetically characterize the identities of these spirochetes in the United States. DNA sequences of four chromosomal loci (the 16S rRNA gene, flaB, gyrB, and glpQ) were determined for eight isolates of B. turicatae and six isolates of B. parkeri, which grouped the spirochetes in...

Lyme disease and relapsing fever are caused by various Borrelia species. Lyme disease borreliae, the most common vector-borne pathogens in both the U.S. and Europe, are transmitted by Ixodes ticks and disseminate from the site of tick bites to tissues leading to erythema migrans skin rash, arthritis, carditis, and neuroborreliosis. Relapsing fever borreliae, carried by ticks and lice, trigger r...

Borrelia persica, a bacterium transmitted by the soft tick Ornithodoros tholozani, causes tick-borne relapsing fever in humans in the Middle East, Central Asia and the Indian peninsula. Immunocompetent C3H/HeOuJ mice were infected intradermally with B. persica at varying doses: 1 x 10(6), 1 x 10(4), 1 x 10(2) and 4 x 10(0) spirochetes/mouse. Subsequently, blood samples were collected and screen...

Technical Appendix Table. Characteristics and clinical and laboratory findings for patients having positive results for TBRF by rtPCR, Jask and Rodan Counties, Iran, 2011–2013* Patient no. Sex Age, y Occupation Area, Province Relapses Microscopy (count/10 high power fields) rt-PCR IGS nested PCR 1 M 22 Unknown Jask, Hormozgan Yes Positive† (2.3) Positive Positive 2 M 59 Farmer Jask, Hormozgan Y...

We report an imported case of louse-borne relapsing fever in a young adult Eritrean refugee who presented with fever shortly after arriving in Switzerland. Analysis of blood smears revealed spirochetes identified as Borrelia recurrentis by 16S rRNA gene sequencing. We believe that louse-borne relapsing fever may be seen more frequently in Europe as a consequence of a recent increase in refugees...

BACKGROUND: Knowledge about the infectious potential of causative agent recurrent tick-borne fever Borrelia miyamotoi and role this pathogen in etiological structure formation transmissible natural focal infections a number regions remains incomplete. Among them is Tomsk region where 2021 incidence ixodic borreliosis was 15.7 per 100,000 population, which 3.6 times higher than all-Russian indic...