Screen-film image receptors have been the standard detector used in conventional mammography. New developments in detector technology and computers are altering the landscape of mammography imaging. Full Field Digital Mammography (FFDM) offers the promise of revolutionizing the practice of mammography through its superior dose and contrast performance. Advanced applications made possible throug...

Primary breast osteosarcoma is a rare malignancy, with mostly case reports in the literature. The appearance of breast osteosarcoma on digital breast tomosynthesis imaging has not yet been described. A 69-year-old woman presents for routine screening mammography and is found to have a calcified mass in her right breast. Pattern of calcification appeared "sunburst" on digital breast tomosynthesi...

Validation of novel x-ray breast image acquisition or analysis systems, based upon the clinical trials, is limited in terms of their cost, duration, and repeated exposure. These limitations have been emphasized by the emergence of digital breast tomosynthesis and breast computed tomography due to their large number of system settings to be tested. Virtual clinical trials have been introduced as...

PURPOSE In medical imaging systems, proper rendition of anatomy is essential in discerning normal tissue from disease. Currently, digital breast tomosynthesis (DBT) systems are evaluated using subjective evaluation of lesion visibility in uniform phantoms. This study involved the development of a new methodology to objectively measure the rendition of a 3D breast model by an anthropomorphic bre...

Digital breast tomosynthesis is a three-dimensional imaging technique that provides an arbitrary set of reconstruction planes in the breast from a limited-angle series of projection images acquired while the x-ray tube moves. Traditional shift-and-add (SAA) tomosynthesis reconstruction is a common mathematical method to line up each projection image based on its shifting amount to generate reco...

We describe the anisotropy in imaging performance caused by oblique x-ray incidence in indirect detectors for breast tomosynthesis based on columnar scintillator screens. We use MANTIS, a freely available combined x-ray, electron, and optical Monte Carlo transport package which models the indirect detection processes in columnar screens, interaction by interaction. The code has been previously ...

PURPOSE In the early development of new imaging modalities - such as tomosynthesis and cone-beam CT (CBCT) - an accurate predictive model for imaging performance is particularly valuable in identifying the physical factors that govern image quality and guiding system optimization. In this work, a task-based cascaded systems model for detectability index is proposed that describes not only the s...

PURPOSE In tomosynthesis, super-resolution has been demonstrated using reconstruction planes parallel to the detector. Super-resolution allows for subpixel resolution relative to the detector. The purpose of this work is to develop an analytical model that generalizes super-resolution to oblique reconstruction planes. METHODS In a digital tomosynthesis system, a sinusoidal test object is mode...