The concentration of a drug in the circulatory system is studied under two different elimination strategies. The first strategy--geometric elimination--is the classical one which assumes a constant elimination rate per cycle. The second strategy--Poisson elimination--assumes that the elimination rate changes during the process of elimination. The problem studied here is to find a relationship b...

The design of rational dosage schedules of tubocurarine to obtain sustained muscular relaxation has recently been described by Ryan (1964). His paper dealt primarily with the time course of tubocurarine concentration or amount in the body; it is intended here to consider the time course of tubocurarine activity. Let it be assumed that the intensity of pharmacological activity of tubocurarine is...

Although Methotrexate (MTX) is an effective drug for the treatment of acute lymphoblastic leukemia (ALL), the toxicity remains a significant problem. In this prospective study, fifty-four patients with ALL were enrolled. 3 g or 5 g MTX/m(2) was administered over 24 hours. Serum MTX concentrations were determined in 24, 48, and 96 hours after MTX infusion. Serum creatinine concentrations and cre...

We submit that adaptation in recombinative evolutionary systems is powered by an implicit form of computation called Hypomixability Elimination. We describe hypomixability elimination, and provide evidence that it can be performed efficiently by recombinative evolutionary systems. Specifically we show that hypomixability elimination in a simple genetic algorithm can be used to obtain optimal bo...

This paper proposed the comparison made between Multi-Carrier Pulse Width Modulation, Sinusoidal Pulse Width Modulation and Selective Harmonic Elimination Pulse Width Modulation technique for minimization of Total Harmonic Distortion in Cascaded H-Bridge Multi-Level Inverter. In Multicarrier Pulse Width Modulation method by using Alternate Position of Disposition scheme for switching pulse gene...

A recently developed three-compartment model for the absorption and elimination of ingested alcohol was applied to re-analyse a study on the effects of various factors known to influence the blood-alcohol curve. The absorption and elimination of alcohol after drinking diluted alcohol were studied in healthy volunteers under strictly standardized conditions. The factors studied were sex, dose, c...

Projections have been made of the number of mesotheliomas, lung cancers, and cases of asbestosis that might occur over the period 1987 to 2020 in former workers at the Wittenoom crocidolite asbestos mine in Western Australia. Predictions were based on the observed mortality to the end of 1986 and modelling of the mesothelioma rate. Elimination of crocidolite from the lungs was included in the m...

The performance of a hybrid bubble column/biofilter (HBCB) bioreactor for the removal of dichloromethane (DCM) from waste gas streams was studied in continuous mode for several months. The HBCB bioreactor consisted of two compartments: bubble column bioreactor removing DCM from liquid phase and biofilter removing DCM from gas phase. Effect of inlet DCM concentration on the elimination capacity ...

In the literature a number of relative loss bounds have been shown for on-line learning algorithms. Here the relative loss is the total loss of the on-line algorithm in all trials minus the total loss of the best comparator that is chosen off-line. However, for many applications instantaneous loss bounds are more interesting where the learner first sees a batch of examples and then uses these e...