Localized proton NMR spectroscopy at 1.5 T using stimulated echoes has been applied to study metabolic alterations in the postischemic phase of patients with acute cerebral infarction. A complete depletion of N-acetyl aspartate in the area of infarction has been observed in a patient studied 4 days after stroke. This finding was paralleled by a dramatic increase in the concentration of lactic a...

Abstract Introduction This study aims to investigate whether nodal metabolic tumour volume (nMTV) and total lesion glycolysis (nTLG) on Fluorine‐18 fluoro‐deoxy‐glucose positron emission tomography–computed tomography ( 18 F‐FDG PET/CT) in inoperable node‐positive stage II III non‐small cell lung cancer (NSCLC) are independent predictors of overall survival (OS) patients undergoing curative‐int...

Fructose 2,6-bisphosphate (F2,6BP) is a powerful allosteric activator of 6-phosphofructo-1-kinase, which is the rate-limiting enzyme for glycolysis. Mitogenic stimulation of lymphocytes is related to an enhanced rate of glucose utilization and F2,6BP mediated activation of glycolysis. To determine the effect of hyperglycemia on intracellular glycolysis of lymphocytes, we measured intracellular ...

Triosephosphate isomerase (TIM) is an essential, highly conserved component of glycolysis. Tumors are often dependent on glycolysis for energy and metabolite production (the Warburg effect). Glycolysis inhibitors thus show promise as cancer treatments. TIM inhibition, unlike inhibition of other glycolysis enzymes, also produces toxic methylglyoxal targeted to regions of high glycolysis, an effe...

Pale, soft, and exudative (PSE) pork is primarily caused by an accelerated rate of postmortem glycolysis resulting in low muscle pH while carcass temperature remains high, thus causing protein denaturation. Numerous factors influence the rate of postmortem metabolism and may be responsible for the rapid pH decline characteristic of PSE pork during the 1st h postmortem. Release of high levels of...

Erythrocyte/Potassium exchange/Radiation Erythrocytes irradiated with 60Co ƒÁ-rays took up more extracellular 42K+ and released more intracellular 42K+ during and immediately after irradiation at 37•Ž than did unirradiated control. The result of K+ transport was contrasted with the well-known K+ loss on prolonged incubation. However, total K+ and ATP levels in irradiated cells did not change si...

Abstract Background Positron emission tomography (PET) is routinely used for cancer staging and treatment follow-up. Metabolic active tumor volume (MATV) as well total MATV (TMATV—including primary tumor, lymph nodes metastasis) and/or lesion glycolysis derived from PET images have been identified prognostic factor or the evaluation of efficacy in patients. To this end, a segmentation approach ...