in this research, we have computationally investigated a mechanism for antiepileptic drugs (aed) and proposed bumetanide as a possible temporal lobe epilepsy (tle) treatment. experimentally it is difficult and devastating to determine the ionic mechanisms of depolarizing currents. it is obvious that chlorine and potassium transients are challenging to isolate pharmacologically and much γ-aminob...

chess is considered as a cognitive game because of severe engagement of the mental resources during playing. the purpose of this study is evaluation of frontal lobe function of chess players with matched non-players. wisconsin card sorting test (wcst) data showed no difference between the player and non-player groups in preservation error and completed categories but surprisingly showed signifi...

background epilepsy, a well-known mostly idiopathic neurologic disorder, has to be correctly diagnosed and properly treated. up to now, several diagnostic approaches have been processed to determine the epileptic focus. objectives the aim of this study was to discover whether proton-mr-spectroscopic imaging (mrsi) aids in the diagnosis of temporal lobe epilepsy in conjunction with classical ele...

introduction: transforming growth factor-beta 1 (tgf-β1) is a pleiotropic cytokine with potent anti-inflammatory property, which has been considered as an essential risk factor in the inflammatory process of ischemic stroke (is), by involving in the pathophysiological progression of hypertension, atherosclerosis, and lipid metabolisms. -509c/t tgf-β1 gene polymorphism has been found to be assoc...

This study investigates machining stability considering the rotational and thermal effects of a spindle-bearing system. Conventional method for analysis only has regarded static response spindle system, which does not represent actual conditions as some investigations mentioned. Bearing stiffness change caused by contact angle is applied to analytical approach dynamics At same time, in frequenc...

The civil aircraft engine business is complex in operation. Being an asset-heavy operating highly engineering systems, the optimized fleet life-cycle management essential yet challenging. aviation systems are known for critical operation conditions, high-standard reliability demands, and high cost both asset value through-life maintenance services. Civil engines typically require 3 to 4 costly ...

The optimum design of a flexible rotor supported on three-lobe bearings, overhung centrifugal compressor, is studied for the optimal unbalance response using the genetic algorithm (GA) and method of feasible directions (MFD). The MFD is used to verify the GA results. The feasibility, effectivness, and avaliability of the GA is certainly of value because it allows the exploration of many differe...

Novel “VIV” signal flow graphs are introduced. They provide a description of active filter subblocks consisting of OpAmps with grounded inputs. The Tow-Thomas, the Åckerberg-Mossberg, the Fleischer-Tow, and MFB structures are typical representatives of such a filter class. Many kinds of active filter like the Sallen-Key utilize a more general OpAmp connection with ungrounded inputs. These circu...

We summarize some of the most frequenthly used rodent animal models of temporal lobe epileps and the impact of chemoconvulsants on them. Temporal lobe epilepsy is the most common epilepsy in humans in which seizures spread to the neighboring cortiase and hippocampal neuron loss and other neuropathological take place. Temporal lobe epilepsy and the other form of epilepsy cannot acquired in chini...

An experiment was designed and carried out to study the friction deformation of carbon fibre tow under sliding transverse orientation fibres. A continuous frictional force measured in reciprocal tests over a length about one width tow, as well incremental 4 mm with stop after each millimetre measure topography contact glass plate. Although coefficient depended on initial state first millimetres...