نتایج جستجو برای: toxic cross
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3 0 9 (celecoxib and valdecoxib) could possibly cross react with sulfonamides. The sulfonamide-type reactions (erythema multiforme, Stevens Johnson syndrome, toxic epidermal necrolysis (TEN) and maculopapular rash) were found to be twice as common with celecoxib as with rofecoxib. The pathogenesis of these reactions is likely to be the same as for sulfonamide induced reactions – T cell mediated...
The Fanconi anemia DNA repair pathway is pivotal for the efficient repair of DNA interstrand cross-links. Here, we show that FA-defective (Fancc(-)) DT40 cells arrest in G2 phase following cross-link damage and trigger apoptosis. Strikingly, cell death was reduced in Fancc(-) cells by additional deletion of the BRCA1 tumor suppressor, resulting in elevated clonogenic survival. Increased resista...
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