conclusions in general, it can be said that the application of nanoliposomal paromomycin sulfate formulations for topical treatment of the cutaneous leishmaniasis does not create serious side effects in the short term, but its long-term use leads to mild renal and liver side effects that requires more attention. background hepatotoxicity due to drugs is the most common cause of deaths. nephroto...

background the increasing use of herbal drugs and their ease of accessibility and availability have necessitated the use of mutagenicity test to analyze their toxicity and safety. objectives this study aimed to evaluate the genotoxicity of sankol herbal medicine in dna breakage of rat hepatocytes in comparison with h2o2 by single cell gel electrophoresis technique or comet assay. materials and ...

background: momordica charantia (m. charantia) seed has been supposed to have an antifertility property but mechanisms underlying the infertility effect have not been investigated. objective: we investigated the antifertility effect of m. charantia ethanol seed extracts on reproductive toxicology and seminal and plasma testosterone in male wistar rats. materials and methods: the control group (...

conclusions the findings of the current study indicate that at high concentrations of salt, the growth of bacteria reduces so that it stops at a concentration of 50 mg l-1 (5%). thus, the bacterium is halotolerant or halophilic. with an increase in phenol concentration, the growth rate increased. phenol toxicity appears at a concentration of 600 mg l-1. results the phenol concentration of 600 m...

organophosphorous (op) pesticides are used frequently in agriculture, particularly in asian countries over the past decades. poisoning by these agents, either as acute or chronic in these nations, is a serious health problem. op pesticides residue in fruits and vegetables that may not induce early clinical features, could also affect the human health. therefore, medical and health professionals...

background: cadmium has toxicological significance and there is no effective therapy for its poisoning. objective: the effects of silymarin on the parameters indicative of cadmium-induced toxicity were studied in rats. methods: 130 adult male wistar rats were divided into 13 groups each comprising 10 rats. 1 group as control group was not administered neither cadmium nor silymarin. cadmium chlo...

many food products are perishable by nature and require protection from spoilage during their preparation, storage and distribution to give them desired shelf-life. because food products are now often sold in areas of the world far distant from their production sites, the need for extended safe shelf-life for these products has also expanded. currently, there is a strong debate about the safety...

introduction: cell culture is a process in which the cells ware isolated from original tissue, dispersed in liquid media and then placed in culture plate where the cells adhere together and propagate. today, this method is used for assessment of cell toxicity, its mechanisms and effect of different compounds on intracellular components. methods: clonogenic assay was used for assessment of cell ...

background: there has been increasing awareness throughout the world regarding the remarkable decrease in amphibian population. for such amphibian population decline several causes have been given. cadmium, a heavy metal is released both from natural sources (leaching of cadmium rich soils) and anthropogenic activities to the aquatic and terrestrial environments. this study evaluated the toxici...

background: tricyclic antidepressants (tcas) poisoning is the most common poisoning in the poisoning emergency department of noor hospital, isfahan, iran. the objective of this study was to compare qrs interval duration with ravr³3mm and r/savr³ 0.7 in predicting: serious complications of acute tca toxicity. methods and materials: this study was descriptive – analytic and prospective cohort. tc...