BACKGROUND The challenge in systematic toxicological analysis using gas chromatography and/or liquid chromatography coupled to mass spectrometry is to identify compounds of interest from background noise. The large amount of spectral information collected in one full-scan MS run demands the use of automated evaluation of recorded data files. We evaluated the applicability of the freeware deconv...

In order to interpret experimental Omics-data, ecotoxicologists are faced with an array of disconnected bioinformatics databases and algorithms. These include tools for microarray analysis, gene annotation, functional gene set enrichment, and network analysis. Drawing together these Web tools and resources is a frequently labour-consuming technical exercise in identifying links across database ...

The Björn Ekwall Memorial Foundation (BEMF) was initiated by the Scandinavian Society for Cell Toxicology in 2001, to honour the memory of Dr Björn Ekwall (1940-2000) and to establish a prize, the Björn Ekwall Memorial Award. The prize is awarded to scientists who have significantly contributed to the field of cell toxicology, and whose work is contributing toward the replacement of animal expe...

Understanding the mechanism of chemical toxicity, which is essential for cross-species and dose extrapolations, is a major challenge for toxicologists. Standard mechanistic studies in animals for examining the toxic and pathological changes associated with the chemical exposure have often been limited to the single end point or pathways. Toxicoproteomics represents a potential aid to the toxico...

One hundred years ago, Warren established for the first time a quantitative link between dose and time while studying the toxicity of sodium chloride in Daphnia magna (Straus). During this century, many toxicologists in different contexts returned to this idea, which has become known as Haber's Rule of inhalation toxicology. Most attempts to explore this relationship ended in frustration becaus...

This is the sixth volume in a series of invited essays devoted to specialized topics in the broad field of toxicology (environmental, clinical, analytical, industrial, and forensic). The five essays in the present collection encompass a variety of subjects. In the opening essay John Autian discusses the toxicology of plasticizers used in medicine, considering the effects of both shortand long-t...

The explosion of knowledge in the fields of biology and chemistry has not gone unnoticed by the toxicologist. pharmacologist, physiologist, or ph sician. Indeed, basic findings in biology and biochemistry have found extrapolation to man, and this scmposium is concerned with how man is served through an understanding of basic factors of living organisms in general. Two basic factors must be cons...

This is the sixth volume in a series of invited essays devoted to specialized topics in the broad field of toxicology (environmental, clinical, analytical, industrial, and forensic). The five essays in the present collection encompass a variety of subjects. In the opening essay John Autian discusses the toxicology of plasticizers used in medicine, considering the effects of both shortand long-t...

BACKGROUND The science of toxicology has a long history and been highly valued in Islamic countries. Numerous scientists were the expert in this field, particularly during the third and fourth centuries. Through reading such literature and gaining the experience of the scientists, one can use such valuable information to promote this science. METHODS In this article, different sources of trad...