In the budding yeast, Saccharomyces cerevisiae, genes in close proximity to telomeres are subject to transcriptional silencing through the process of telomere position effect (TPE). Here, we show that the protein Ku, previously implicated in DNA double-strand break (DSB) repair and in telomeric length maintenance, is also essential for telomeric silencing. Furthermore, using an in vivo plasmid ...

Trianthema portulacastrum, a medicinal and dietary plant, has gained substantial importance due to its various pharmacological properties, including anti-inflammatory and anticarcinogenic activities. We have recently reported that a characterized T. portulacastrum extract (TPE) affords a considerable chemoprevention of 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumorigenesis thou...

The aim of this study was to explore the diagnostic value of IL-31 levels in the pleural fluid and plasma to differentially diagnose tuberculous and malignant pleural effusion. We enrolled 91 cases, including tuberculous pleural effusion (TPE, n = 50), malignant pleural effusion (MPE, n = 41), other cases including pneumonia with pleural fluid, pulmonary tuberculosis and healthy people as contr...

reduced and their return to baseline values may take days, even in patients with normal liver function [9] . Although a reduction of coagulation parameters in general does not necessarily imply more hemorrhagic complications [10] , a low fibrinogen concentration is definitely associated with an increased bleeding risk [11] . This bleeding diathesis is also prolonged in TPEtreated patients with ...

A crown ether-functionalized poly(tetraphenylethene) (AP-TPE) is synthesized and the rotation of the TPE group is successfully restricted via the complexation of crown ether and organic ammonium salts, leading to a stepwise enhanced fluorescence accompanied by a morphological transition from micellar to vesicular.

Tetraphenylethylene is a prototypical example of a molecule displaying aggregation-induced emission. Despite many studies on the optical properties of TPE and its derivatives, the origin of the non-emissive behavior in the gas phase or in dilute solutions has yet to be unravelled. Here, we identify the ultrafast deactivation mechanisms responsible for the fluorescence quenching in isolated TPE.

Effective field theory (EFT) approach, which shed new light on the methodology of nuclear physics, was used to reformulate the parity-violating (PV) nucleon-nucleon (NN) interaction recently,1 and the potential has been applied to a few two-nucleon problems.2,3 The PV two-pion-exchange (TPE) contribution to physical observables turned out to be non-negligible, but was not so significant as the ...

In this note1 we consider effects of a Two-Photon Exchange (TPE) in inclusive DIS and semi-inclusive DIS (SIDIS). In particular, transverse single spin asymmetries are generated in inclusive DIS if more than one photon is exchanged between the lepton and the hadron. We briefly summarize the TPE in DIS in the parton model and extend our approach to SIDIS, where a new leading twist sin(2φ) contri...

Five novel fluorescent materials, TT-TPA, TT-TPE, TPA-TT-TPA, TPE-TT-TPE, and TPA-TT-TPE, containing a strongly electron-donating triphenylamine (TPA) bulky tetraphenylethylene (TPE), linked through thienothiophene, 4-thieno[3,2-b]thiophen-3-ylbenzonitrile, possessing electron-withdrawing nitrile moiety, were systematically designed, synthesized, their optical electrochemical properties compare...

Background—Transmural dispersion of repolarization (TDR) may be related to the genesis of torsade de pointes (TdP) in patients with the long-QT (LQT) syndrome. Experimentally, LQT2 models show increased TDR compared with LQT1, and -adrenergic stimulation increases TDR in both models. Clinically, LQT1 patients experience symptoms at elevated heart rates, but LQT2 patients do so at lower rates. T...