The genotoxic potential of total particulate matter (TPM) from mainstream smoke (MS) and sidestream smoke (SS) of Indian smoking products, namely cigarettes and bidis, as well as a brand of US cigarettes, was studied by determining the levels of bulky aromatic DNA adducts in mouse tissues. TPM from MS or SS of various smoking products [equal weights (2.5 mg) or the amount derived from equal (0....

Objective Anorexia and impaired appetite (Dysorexia) are common symptoms with varying causes, and often need no serious medical intervention. Anorexia nervosa (AN) is a chronic psychiatric disease with a high mortality rate. In Traditional Persian Medicine (TPM), anorexia is a condition in which anorexic patients lose appetite due to dystemperament. This review aims to discuss the common points...

In this communication, the effect of acute treatment with lamotrigine (LTG) and topiramate (TPM) was investigated on release of the main excitatory amino acids (EAA) such as glutamate (Glu) and aspartate (Asp) in the hippocampus of pentylenetetrazol (PTZ)-kindled freely moving rats using microdialysis. The results showed that the level of Glu and Asp significantly decreased in the PTZ-kindled e...

For the traditional threshold signature mechanism does not considers whether the nodes which generate part signature are trusted and the traditional signature strategy doesn’t do well in resisting internal attacks and external attacks and collusion attacks, so this paper presents a new threshold signature based on Trusted Platform Module (TPM), based on TPM the signature node first should finis...

BACKGROUND Obesity is a serious chronic disease. Controlled-release phentermine/topiramate (PHEN/TPM CR), as an adjunct to lifestyle modification, has previously shown significant weight loss compared with placebo in a 56-wk study in overweight and obese subjects with ≥2 weight-related comorbidities. OBJECTIVE This study evaluated the long-term efficacy and safety of PHEN/TPM CR in overweight...

Assume that the user a trusted computing platform communicates with a verifier who wants to be assured that the user indeed uses a platform that can be trusted. trusted hardware module, This problem is called remote attestation and discussed in detail in Chapter ??. As described there, the problem in the end boils down to the problem that a trusted platform module (TPM) needs to prove that the ...

BACKGROUND AND OBJECTIVE Very few drugs are approved for obesity treatment by regulatory agencies. Very recently phentermine/topiramate controlled-release [PHEN/TPM CR; (Qsymia®)] obtained Food and Drug Administration (FDA) approval as an addition to a reduced-calorie diet and exercise for chronic weight management. Our aim was to review the available clinical evidence on weight loss, metabolic...

This paper reviews the results of placebo-controlled trials on topiramate (TPM) in the prophylaxis of migraine, focusing particularly on efficacy and tolerability of the target dose (100 mg/day). Data from well-conducted trials and analyses of pooled data show that TPM is effective against migraine, confirming the experience of physicians in various countries. High responder rate and good toler...

We discuss five attack strategies against BitLocker, which target the way BitLocker is using the TPM sealing mechanism. BitLocker is a disk encryption feature included in some versions of Microsoft Windows. It represents a state-of-the-art design, enhanced with TPM support for improved security. We show that, under certain assumptions, a dedicated attacker can circumvent the protection and brea...

We implement an encrypted file system that uses a Trusted Platform Module (TPM) to securely store file encryption keys. Key management is centralized. We identified the ability of a key server to verify deletion of file encryption keys on clients to reduce the amount of re-encryption necessary on key revocation. We place the TPM on the file-read datapath and encrypt files with RSA. In benchmark...