Total parenteral nutrition (TPN), or the complete absence of enteral nutrients, is commonly used in a clinical setting. However, a major consequence of TPN administration is the development of mucosal atrophy and a loss of epithelial barrier function (EBF); and this loss may lead to an increase in clinical infections and septicemia. Our laboratory has investigated the mechanism of this TPN-asso...

Previous studies have provided conflicting conclusions concerning the efficacy of improving protein balance in patients by standard intravenous nutrition [TPN (total parenteral nutrition)], which is either explained by suboptimal nutritional regimens or insensitive clinical methods. The aim of the present study was therefore to evaluate the effects on the initiation of translation of skeletal m...

PURPOSE Tpn is a member of the MHC class I loading complex and functions to bridge the TAP peptide transporter to MHC class I molecules. Metastatic human carcinomas often express low levels of the antigen-processing components Tapasin and TAP and display few functional surface MHC class I molecules. As a result, carcinomas are unrecognizable by effector CTLs. The aim of this study is to examine...

BACKGROUND & AIMS Total parenteral nutrition (TPN), a crucial treatment for patients who cannot receive enteral nutrition, is associated with mucosal atrophy, barrier dysfunction, and infectious complications. Glucagon-like peptide-2 (GLP-2) and epidermal growth factor (EGF) improve intestinal epithelial cell (IEC) responses and attenuate mucosal atrophy in several TPN models. However, it remai...

OBJECTIVES To study the interrelationship between serum Interleukin-6 (IL-6), serum Interleukin-6 soluble Receptor (IL-6 sR), C-Reactive Protein (C-RP), plasmatic Zinc levels (PlZn) and their response in relation to Zn administered by TPN, in critical patients. METHODS 17 patients, receiving TPN as a consequence of acute pancreatitis (n = 4) or after a major abdominal surgery due to intestina...

BACKGROUND Major depressive disorder (MDD) has been associated reliably with ruminative responding; this kind of responding is composed of both maladaptive and adaptive components. Levels of activity in the default-mode network (DMN) relative to the task-positive network (TPN), as well as activity in structures that influence DMN and TPN functioning, may represent important neural substrates of...

The prevalence of short bowel syndrome appears to be increasing because of more aggressive surgical and medical approaches to the management of neonatal intraabdominal catastrophies. Hence, a large cohort of neonates with intestinal failure occupies neonatal intensive care units, requiring chronic total parenteral nutrition (TPN) in hopes that the residual bowel will adapt, thereby permitting w...

To carry out performance evaluation of an asynchronous system, the system is modeled as Time Petri Net (TPN) and an iteration of Petri net simulations produces its performance index. The TPN model needs to satisfy required properties such as deadlock freeness. We proposed a symbolic representation of TPN for SAT-based bounded model checking. In the proposed encoding scheme, firing of transition...

Abstract: IRIS (increasing reward with increasing service) realtime scheduling appears frequently in real-time control applications such as heuristic control. IRIS requires not only meeting deadlines, but also finding the schedule with the best result (highest reward). In this paper, a framework is presented that uses Timed Petri nets (TPN) to transform an IRIS problem into a dynamic programmin...

This paper introduces TPN, the runner up method in both tasks of the ECML-PKDD Discovery Challenge 2006 on personalized spam filtering. TPN is a classifier training method that bootstraps positive-only learning with fully-supervised learning, in order to make the most of labeled and unlabeled data, under the assumption that the two are drawn from significantly different distributions. Furthermo...