Female-specific splicing of Drosophila doublesex (dsx) pre-mRNA is regulated by the products of the transformer (tra) and transformer 2 (tra2) genes. In this paper we show that Tra and Tra2 act by recruiting general splicing factors to a regulatory element located downstream of a female-specific 3' splice site. Remarkably, Tra, Tra2, and members of the serine/arginine-rich (SR) family of genera...

We consider networks where tra c is served according to the Generalised Processor Sharing (GPS) principle. GPS-based scheduling algorithms are considered important for providing di erentiated quality of service in integrated-services networks. We are interested in the workload of a particular ow i at the bottleneck node on its path. Flow i is assumed to have long-tailed tra c characteristics. W...

In recent years, numerous publications have identi ed a high number of tra c sources to be of self-similar nature. Such tra c can have a negative impact on traditional queuing systems. This paper presents a call admission control algorithm that uses periodic wavelet analysis applied to tra c measurements to estimate the amount of resources necessary to support a certain set of connections under...

A series of 102 transfer-deficient (tra(-)) mutants of Flac (84 of which have been previously described) were classified as carrying frameshift, amber, ochre, UGA, and nonsuppressible mutations. Techniques were evolved for using cultures of F prime strains as efficient recipients in matings, for measuring the number of (F'/F') heterozygote cells in transient populations, and for measuring compl...

BACKGROUND Compared to the transfemoral approach (TFA), the transradial approach (TRA) for primary percutaneous coronary intervention (PCI) is associated with less risk of access site complications, greater patient comfort and faster mobilisation. Using vascular closure devices during TFA can offer similar advantages. AIM To compare the results of TRA and TFA using a StarClose device for prim...

Establishment of self-tolerance in the thymus depends on promiscuous expression of tissue-restricted Ags (TRA) by thymic epithelial cells (TEC). This promiscuous gene expression (pGE) is regulated in part by the autoimmune regulator (AIRE). To evaluate the commonalities and discrepancies between AIRE-dependent and -independent pGE, we analyzed the transcriptome of the three main TEC subsets in ...

Recent measurements of packet networks have shown that packet tra c exhibits long-range-dependent property. Studies have also discovered that this property is not adequately captured by the conventional Markov tra c models and often yields queueing behavior such as heavy-tailed or subexponential queue length distribution. These ndings have led to the implication that long-range-dependent tra c ...

Lactating breast tissue and some breast cancers express the sodium/iodide symporter (NIS) and concentrate iodide. We recently demonstrated that all-trans retinoic acid (tRA) induces both NIS gene expression and iodide accumulation in vitro in well-differentiated human breast cancer cells (MCF-7). In the present study, we investigated the in vivo efficacy and specificity of tRA-stimulated iodide...

We have recently shown that all-trans retinoic acid (tRA) modulates arterial smooth muscle cell (SMC) morphologic features and biochemical composition in vitro. It has been proposed that different SMC phenotypes coexist in arteries, which may be retrieved in culture: hence, a differential action of tRA on distinct SMC subsets is conceivable. We have examined the effect of tRA on SMC proliferati...

OBJECTIVES The aim was to study transradial approach (TRA) and transfemoral approach (TFA) in terms of feasibility, effectiveness, usefulness, and procedure characteristics in patients having ST-segment elevation myocardial infarction (STEMI) and undergoing primary percutaneous coronary intervention (PCI). Along with the said aim, major adverse cardiovascular events (MACE) at follow-up were als...