This paper describes a new method for the transannular functionalization of γ-C−H bonds in alicyclic amines to install C(sp3)−halogen, oxygen, nitrogen, boron, and sulfur bonds. The key challenge this transformation is controlling relative rate Cγ−H versus Cα−H functionalization. We demonstrate that selectivity can be achieved by pre-complexation substrate with Pd prior addition oxidant. approa...

Cyclocondensation between 4,4`-bis(4-chlorobenzenesulfonyl)biphenyl and catechol, with subsequent chromatographic separation of the reaction products, led to isolation four novel ether-sulfone macrocycles (cyclic dimer, -trimer, -tetramer -pentamer). Similarly, cyclocondensation catechol a seven-ring diketone/disulfone monomer allowed two new aromatic ether-ketone-sulfone macrocycles, cyclic di...

Arginine-vasopressin was subjected to a long (11 μs) molecular dynamics simulation in aqueous solution. Analysis of the results by DASH and principal components analyses revealed four main ring conformations that move essentially independently of the faster-moving tail region. Two of these conformations (labeled "saddle") feature well-defined β-turns in the ring and conserved transannular hydro...

Guido Krämer, Annette Oehlhof, and Herbert Meier Institute of Organic Chemistry, University of Mainz, Duesbergweg 10 – 14, 55099 Mainz, Germany Reprint requests to Prof. Dr. H. Meier. Fax: +49-(0)6131-3925396. E-mail: [email protected] Z. Naturforsch. 2009, 64b, 847 – 850; received April 8, 2009 Hydroxycycloalkanones 1 of medium ring size (8 – 10) exist in a transannular tautomeric equil...

BACKGROUND Although surgical treatment for tetralogy of Fallot (TOF) has been used with considerable success, right ventricular function may remain altered after repair. The NT-proBNP assessment has been shown to be a reliable parameter for the heart failure assessment. AIM To determine NT-proBNP values in assessment of right ventricular function in children after TOF correction. METHODS In...

Supramolecular assembly 1 catalyzes a bimolecular aza-Prins cyclization featuring an unexpected transannular 1,5-hydride transfer. This reaction pathway, which is promoted by constrictive binding within the supramolecular cavity of 1, is kinetically disfavored in the absence of 1, as evidenced by the orthogonal reactivity observed in bulk solution. Mechanistic investigation through kinetic anal...