Purpose of the study The first antiretroviral therapy was introduced in Vietnam in 1990 and included two nucleoside reverse transcriptase inhibitors (NRTIs). More recently, nonnucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs) were available, particularly through different programmes. In this context, it is interesting to survey the HIV drug resistance and also t...

Submit Manuscript | http://medcraveonline.com Abbreviations: ART: Antiretroviral Therapy; NNRTI: NonNucleoside Reverse Transcriptase Inhibitor; NRTI: Nucleoside/N Ucleotide Reverse Transcriptase Inhibitor; PI: Protease Inhibitor; AZT: Zidovudine; D4T: Stavudine; DDI: Didanosine; TDF: Tenofovir Disoproxil Fumarate; EFV: Efavirenz; NVP: Nevirapine; ETR: Etravirine; LPV/R: Lopinavir and Ritonavir;...

The prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) mutations was determined among 95 human immunodeficiency virus-infected Thai children who were treated with dual nucleoside reverse-transcriptase inhibitors. Almost all children had resistance to at least 1 NRTI, and approximately half of the children had resistance to multiple NRTIs. Cross-resistance to stavudine and azidothym...

Telomerase is a specialized reverse transcriptase responsible for the de novo synthesis of telomeric DNA repeats. In addition to its established reverse transcriptase and terminal transferase activities, recent reports have revealed unexpected cellular activities of telomerase, including RNA-dependent RNA polymerization. This telomerase characteristic, distinct from other reverse transcriptases...

Highly active antiretroviral therapy (HAART) consists of a combination of drugs to achieve maximal virological response and reduce the potential for the emergence of antiviral resistance. Despite being the first antivirals described to be effective against HIV, reverse transcriptase inhibitors remain the cornerstone of HAART. There are two broad classes of reverse transcriptase inhibitor, the n...

In this study, the interaction between human immunodeficiency virus reverse transcriptase and methyldiarylpyrimidines containing a hydroxyimino, hydrazine, hydroxyl, cyclopropylamino, cyano or chloro etc. substituent was studied by molecular docking simulation, accomplished with AutoDock4.2 absorption, distribution, metabolism, excretion toxicity-structure-activity relationship Swiss metabolism...