Background Proponents of clinical case formulations argue that the causes and mechanisms contributing to maintaining a patient's problems should be analysed integrated into conceptualization, on which treatment planning ought based. Empirical evidence shows an individualized based formulation is at least sometimes better than standardized evidence-based treatment. Methods We it likely improve d...

Borderline personality disorder (BPD) is a severe, difficult-to-treat psychiatric condition that represents a large proportion of treatment-seeking individuals. BPD is characterized by high rates of co-occurrence with depressive and anxiety disorders, and recently articulated conceptualizations of this comorbidity suggest that these disorders may result from common temperamental vulnerabilities...

Intolerance of uncertainty (IU) is indicated as an important transdiagnostic process variable in a range of anxiety disorders. Anxiety is very common in children with autism spectrum disorders (ASD). This study aimed to develop a parent group based manualised treatment programme for young people with ASD, which focused on IU. An eight session programme was developed and then delivered to 11 par...

The positive valence system (PVS) is an important yet understudied treatment target in anxiety and depression. A pilot trial (NCT02330627) evaluating the efficacy of Amplification Positivity (AMP), a new transdiagnostic activity intervention protocol for depression, showed that, compared to waitlist control group, patients group had significantly larger improvements affect—returning participant...

Anxiety sensitivity (AS) is associated with various forms of psychopathology. The most common measure of AS is the anxiety sensitivity index-3 (ASI-3). The current study examined the psychometric properties and factor structure of the ASI-3 in an acute and comorbid population seeking treatment for a broad range of psychopathology (N=382). Results confirmed a bi-factor structure and suggested th...

Rumination and worry, two forms of perseverative thinking, hold promise as core processes that transect depressive and anxiety disorders. Whereas previous studies have been limited to the laboratory or to single diagnoses, we used experience sampling methods to assess and validate rumination and worry as transdiagnostic phenomena in the daily lives of individuals diagnosed with Major Depressive...