aim :  to evaluate the association of dnmt1 and mgmt amino acid substitution polymorphisms and colorectal cancer in iranian population. background : the mgmt and dnmt1 are two important methyltransferase enzymes. amino acid substitution polymorphisms in mgmt and dnmt1 genes may be associated with the genetic susceptibility to sporadic colorectal cancer. patients and methods : we assessed eight ...

The y-glutamyl transferase isoenzymes of bile were studied using electrophoretic, gel filtration, and ultracentrifugation techniques. In view of the known association of other biliary enzymes with lipids the effects of butanol extraction were investigated. The results show the presence of four isoenzymes ofy-glutamyl transferase in bile, differing in electrophoretic mobilities, molecular size, ...

Serum gamma-glutamyl transferase (GGT) has been widely used as an index of liver dysfunction and marker of alcohol intake. The last few years have seen improvements in these areas and advances in understanding of its physiological role in counteracting oxidative stress by breaking down extracellular glutathione and making its component amino acids available to the cells. Conditions that increas...

Peptide bond formation on the ribosome takes place in an active site composed of RNA. Recent progress of structural, biochemical, and computational approaches has provided a fairly detailed picture of the catalytic mechanism of the reaction. The ribosome accelerates peptide bond formation by lowering the activation entropy of the reaction due to positioning the two substrates, ordering water in...

Two distinct cell populations with lymphoblastic and monocytic characteristics were separated and characterized by multiple cell markers in a patient with terminal transferase-positive acute acute leukemia. The clinical course and sequential cell marker studies were consistent with the interpretation of a defect at the level of a common stem cell giving rise to a terminal transferase--positive ...

This study aimed to obtain resistance information of S. litura from Karangpawitan and Lembang districts (West Java, Indonesia) against chlorpyrifos insecticides (200 g/l) their sensitivity oil mixture A . indica C nardus (1:1) using feeding topical assay. The activity acetylcholinesterase, esterase, glutathione s-transferase larvae in both populations were tested determine role insect resistanc...

The aim of the present study was to investigate effect antihistamines(Chlorpheneramineand Fexofenadine) on (alkaline phosphatase, aspartate amino transpherase and alanine transferase) in tissue fertilized hens eggs embryos as indicator damage. injection hen's with antihistamines Fexofenadine at 12th day incubation doses (0,5,0,1mg/ egginto air sell)after 24 hour treatment induce significantly d...

Our first investigations of the action of lysozyme on tetrasaccharides isolated from chitin showed that lysozyme, like many other known glycosides, is a transferase. Under certain conditions (oligosaccharide concentration 1 to 2% , the enzyme concentration 0*5 %) the synthetic process may yield an insoluble chitin-like product. Judging by the increase of the Morgan-Elson reaction, lysozyme dige...

In a preceding paper it was shown that low concentrations of diphtheria toxin, in the presence of NAD 1 as an essential cofactor, inhibit the incorporation of amino acids into TCA-precipitable peptides in mammalian cell extracts (1). Collier (2) has demonstrated that this inhibitory action of the toxin is due to the specific inactivation of transferase II , one of the highly labile soluble enzy...