Insulin-like growth factor-I (IGF-I)-mediated growth of cells can be modulated by specific IGF binding proteins (IGFBPs) that inhibit or augment IGF-I ligand-receptor interaction. IGFBP expression and production by human intestinal muscle cells in culture was characterized in rapidly growing cells ( day 3 of culture), in confluent cells ( day 7), and in postconfluent cells ( day 14). RT-PCR ana...

There is strong evidence to implicate transforming growth factor-beta in the remodeling that occurs in asthma, as levels are increased in bronchial lavage fluid and gene expression is increased in bronchial tissue. Transforming growth factor-beta is also known to increase the release of collagen from airway smooth muscle. Here we identify for the first time a possible mechanism for the effects ...

Abbreviations: 1,2-dimyristyloxypropyl-3-dimethyl-hydroxyl ethyl ammonium bromide, (DMRIE); activation protein-1, (AP-1); Basement membranes, (BM); colony stimulating factor (CSF), dioleoylphosphatidyl ethanolamine, (DOPE); fibroblast growth factor, (FGF); growth hormone, (GH); Hepatocyte growth factor, (HGF); insulin-like growth factor-I, (IGF-I); interleukin-1, (IL-1); interleukin-6, (IL-6); ...

Uncontrolled elastase activity is involved in the development of several types of lung disease. Previous reports demonstrated that growth factors are liberated from pulmonary matrix storage sites by elastase; however, release of these entities in vivo is not well defined. In the present study, we investigated the release of fibroblast growth factor-2 (FGF-2) and transforming growth factor-beta ...

BACKGROUND The clinical relevance of transforming growth factor-beta (TGF-beta)-signalling pathway in breast carcinomas (BCs) remained elusive. This study aimed to evaluate the prognostic value of TGF-beta1 and transforming growth factor-beta type II receptor (TGF-betaRII) expression levels in tumour cells and their association with the established biomarkers in BC. PATIENTS AND METHODS In 32...