Genetic mouse models for Alzheimer's disease (AD) have been widely used to understand aspects of the biology of the disease, but have had limited success in translating these findings to the clinic. In this review, we discuss the benefits and limitations of existing genetic models and recent advances in technologies (including high throughput sequencing and genome editing) that promise more pre...

Some source texts are more difficult to translate than others. One way to handle such texts is to modify them prior to translation. Yet, a prominent factor that is often overlooked is the source translatability with respect to the specific translation system and the specific model that are being used. We present an approach, and an interactive tool implementing it, where source sentences are re...

This paper presents a preliminary evaluation of a set of Controlled Language (CL) rules selected within the framework of a research project on Machine Translation (MT). The main objective of this project is to improve the machine translatability of an English corpus. This corpus has been obtained from a global Internet security technology company, Symantec. The corpus contains XML alert notific...

In this article we provide a detailed study of basic properties of the smallest universal integral IS with S being the underlying semicopula and review some of the recent developments in this direction. The class of integrals under study is also known under the name seminormed integrals and includes the well-known Sugeno as well as Shilkret integral as special cases. We present some representat...

Asymmetrically distributed cytoplasmic determinants collectively termed germ plasm have been shown to play an essential role in the development of primordial germ cells (PGCs). Here, we report the identification of a nanos-like (nanos1) gene, which is expressed in the germ plasm and in the PGCs of the zebrafish. We find that several mechanisms act in concert to restrict the activity of Nanos1 t...

This paper discusses the problem of untranslatability between Chinese and English, including linguistic and cultural untranslatability. English belongs to the Indo-European language family, and Chinese belongs to the Sino-Tibetan language family. The phonemic system, character structure and figure of speech are all completely different, and most of these in one language do not have equivalent i...

The central dogma states that DNA is transcribed to generate RNA and that the mRNA components are then translated to generate proteins; a simple statement that completely belies the complexities of gene expression. Post-transcriptional regulation alone has many points of control, including changes in the stability, translatability or susceptibility to degradation of RNA species, where both cis-...