نتایج جستجو برای: transmigration

تعداد نتایج: 1871  

2011
Jennifer Lohr Thomas Ratliff Andrea Huppertz Yingzi Ge Christine Dictus Rezvan Ahmadi Stefan Grau Nobuyoshi Hiraoka Volker Eckstein Rupert C. Ecker Thomas Korff Andreas von Deimling Andreas Unterberg Philipp Beckhove Christel Herold-Mende

Purpose: In glioma—in contrast to various other cancers—the impact of T-lymphocytes on clinical outcome is not clear. We investigated the clinical relevance and regulation of T-cell infiltration in glioma. Experimental Design: T-cell subpopulations from entire sections of 93 WHO II–IV gliomas were computationally identified using markers CD3, CD8, and Foxp3; survival analysis was then done on p...

Journal: :American journal of physiology. Cell physiology 2002
Ranjit Giri Suresh Selvaraj Carol A Miller Florence Hofman S D Yan David Stern Berislav V Zlokovic Vijay K Kalra

During normal aging and amyloid beta-peptide (Abeta) disorders such as Alzheimer's disease (AD), one finds increased deposition of Abeta and activated monocytes/microglial cells in the brain. Our previous studies show that Abeta interaction with a monolayer of normal human brain microvascular endothelial cells results in increased adherence and transmigration of monocytes. Relatively little is ...

2011
Csilla Fazakas Imola Wilhelm Péter Nagyőszi Attila E. Farkas János Haskó Judit Molnár Hannelore Bauer Hans-Christian Bauer Ferhan Ayaydin Ngo Thi Khue Dung László Siklós István A. Krizbai

Malignant melanoma represents the third common cause of brain metastasis, having the highest propensity to metastasize to the brain of all primary neoplasms in adults. Since the central nervous system lacks a lymphatic system, the only possibility for melanoma cells to reach the brain is via the blood stream and the blood-brain barrier. Despite the great clinical importance, mechanisms of trans...

Journal: :The Journal of Experimental Medicine 1996
S P Colgan A L Dzus C A Parkos

Polymorphonuclear leukocytes (PMN) are central to the pathogenesis of a number of intestinal diseases. PMN-induced damage to the protective epithelium occurs in hemorrhagic shock, necrotizing enterocolitis and conditions resulting in intestinal reperfusion injury. In such diseases, tissue hypoxia has been implicated as a pathophysiologic mediator. Thus, we hypothesized that exposure of intestin...

Journal: :Journal of Biological Chemistry 2001

Journal: :The Journal of Nihon University School of Dentistry 1964

Journal: :Investigative ophthalmology & visual science 2012
João M Furtado Arpita S Bharadwaj Liam M Ashander Antoinette Olivas Justine R Smith

PURPOSE Toxoplasma gondii, the parasite responsible for ocular toxoplasmosis, accesses the retina from the bloodstream. We investigated the dendritic cell as a potential taxi for T. gondii tachyzoites moving across the human retinal endothelium, and examined the participation of adhesion molecules and chemokines in this process. METHODS CD14-positive monocytes were isolated from human periphe...

Journal: :The Journal of Cell Biology 1992
C A Parkos S P Colgan C Delp M A Arnaout J L Madara

Migration of polymorphonuclear leukocytes across epithelia is a hallmark of many inflammatory disease states. Neutrophils traverse epithelia by migrating through the paracellular space and crossing intercellular tight junctions. We have previously shown (Nash, S., J. Stafford, and J.L. Madara. 1987. J. Clin. Invest. 80:1104-1113), that leukocyte migration across T84 monolayers, a model human in...

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