cause movement disorders. CT brain and chest radiograph were normal. It was decided not to perform MRI brain as it was felt that the probability of an ischaemic lesion not visualised by CT was very low. Routine bloods demonstrated no abnormalities in the full blood count, liver function or renal function. The patient had been noted to be hyponatraemic for at least 2 years (around 125–130 mmol/l...

OBJECTIVE To test the ability of a 5HT2a/c (trazodone) antagonist, to improve depression and motor function in Parkinson' disease (PD). METHOD Twenty PD patients with and without depression were randomly assigned to receive trazodone (group 1) or not (group 2). They were evaluated through UPDRS and Hamilton Depression Rating Scale (HAM-D). RESULTS For the UPDRS the mean score of group 2 was...

Loss-of-function mutations in SCN1A cause Dravet syndrome (DS), a catastrophic childhood epilepsy in which patients experience comorbid behavioral conditions, including movement disorders, sleep abnormalities, anxiety, and intellectual disability. To study the functional consequences of voltage-gated sodium channel mutations, we use zebrafish with a loss-of-function mutation in scn1lab, a zebra...

Insomnia remains under-diagnosed and poorly treated despite its high economic and social costs. Though previous work has examined how patient characteristics affect sleep medication prescriptions, the role of physician characteristics that influence this clinical decision remains unclear. We sought to understand patient and physician factors that influence sleep medication prescribing patterns ...