Effects of Pongamia pinnata, an indigenous plant used in Ayurvedic Medicine in India on the temporal variations of circulatory lipid peroxidation products and antioxidants in ammonium chloride-(AC)-induced hyperammonemic rats has been studied. Experimental rats were divided into control, AC-treated, those treated with AC + ethanolic leaf extract of P. pinnata (PPEt), and PPEt-treated. The...

diabetes is a metabolic disorder which affects whole body systems including reproductive system. diabetes is also a contributing factor to infertility. metformin is one of the most common drugs to control hyperglycemia. in this study, 36 adult sprague-dawley female rats (170-210 g) were divided into 3 groups (control, diabetic and diabetic-treated by metformin). in second and third groups, diab...

Aim The intraglomerular mesangial cells are located between the glomerular capillaries. Here we hypothesized that regulate single nephron filtration rate (snGFR) and support integrity of barrier. Methods We assessed function in vivo by multiphoton microscopy. Mesangial were depleted Munich Wistar Froemter rats using Thy1.1 antibody model. Results caused cell-specific loss 82 ± 3% cells. After c...

The effects of Tahitian noni juice (TNJ), vitamin C and vitamin E on male reproductive functions in cyclophosphamide-treated wistar rats were compared. Thirty five male wistar rats with mean body weight of 180 ± 24.3 g were randomly divided into five groups. Group one were treated with cyclophosphamide (50 mg/kg, i.p.) while, group two were treated with TNJ (10 ml/kg, i.p.) and cyclophosphamide...

Mitochondrial dysfunction is common in the brain with age. Prevention of mitochondrial at an early age may protect against neurodegeneration later life. Tocotrienol-rich fraction (TRF) has been reported to be neuroprotective old rats, but its effect remains unknown for middle-aged animals. This study aimed determine TRF on activities respiratory chain complexes hippocampus rats. Male Sprague Da...

background: para-nonylphenol (p-np) is one of the environmental pollutants which cause reproductive system disorders. objective: the effects of vitamin e on ovary structure during its development in rats treated with p-np. materials and methods: 32 wistar female rats after mating were divided into 4 groups; control vitamin e (100mg/kg/day) p-np (250mg/kg/day) and p-np + vitamin e. the rats were...

objective: the role of wnt signaling and its antagonist; secreted frizzled related protein type 4 (sfpr4) was reported in rodent ovarian follicular development. this study examines immunolocalization of sfrp4 in ovaries of polycystic ovary (pco) rat model and evaluates its role in follicular growth arrest and its premature differentiation. materials and mathods: pco was induced with daily admin...

Abstract* Introduction: Cannabis consumption during pregnancy may affect fetal growth, motor performance, memory and cognitive functions. Methods: Primiparous pregnant Wistar rats were randomly assigned to 4 treatment groups (6 rats per group) consisting of control and sham groups as well as 2 groups treated with Win. Win treated groups received daily s.c. injections of 0.5 or 1 mg/kg WIN ...

this study was conducted to investigate the hepatoprotective and antioxidant effects of pentoxifylline (ptx) against aflatoxin b1 (afb1) exposure in perfused rat livers by evaluating damage marker enzymes, antioxidant defense systems (glutathione, gsh) and lipid peroxidation (malondialdehyde, mda). sixteen rats were divided randomly into four experimental groups: control, ptx, afb1 and afb1 + p...

Diabetic rats in long-term display an augmented nociceptive response to chemical, mechanical, and thermal stimuli. Furthermore, hyperalgesia is one of the major symptoms of diabetic neuropathy in some patients. Considering the antidiabetic potential of pepper, this study was conducted to evaluate the possible analgesic effect of pepper-mixed food intake in male streptozotocin-induced diabetic r...