Introduction: There are several controversies in the treatment strategy for multiple CRLM. Methods: Two hundred and fifty-eight patients underwent initial hepatectomy CRLM from 2001 to 2018. Clinicopathological data long-term outcomes were retrospectively analyzed. Results: MST 5-year OS 46 months 41.6%, which significantly worse compared that with solitary (Group S) (125 69.2%, p<0.001). R1 re...