Objective: To determine the frequency of underlying causes of pyrexia of unknown origin on bone marrow examination. Study Design: Descriptive study. Place and Duration of Study: The study was carried out at Hematology department (pathology) of Army Medical College, National University of Sciences and Technology (NUST) and Military Hospital Rawalpindi (during the period of one year) from Jan 201...

BACKGROUND Bone-targeted agents are widely used for the treatment of osteoporosis, the prevention of cancer-therapy induced bone loss, and for reducing the risk of skeletal related events in patients with metastatic disease. Despite widespread use, relatively little is known about the in vivo effect of these agents on bone homeostasis, bone quality, and bone architecture in humans. Traditionall...

OBJECTIVE To determine the frequency of bone marrow involvement in patients of Hodgkin's lymphoma on first presentation at oncology department. STUDY DESIGN Case series. PLACE AND DURATION OF STUDY The Oncology Department, Combined Military Hospital, Rawalpindi, from April 2006 to February 2007. METHODOLOGY Thirty five patients of Hodgkin's lymphoma diagnosed on lymph node biopsy presenti...

Flow cytometry is the preferred method of diagnosing and immunophenotyping acute lymphoblastic leukemia (ALL). However, there are situations in which immunohistochemical staining (IH) of bone marrow trephine biopsy specimens can be used to provide immunophenotypic information. To evaluate the use of IH and to confirm its value in diagnosing and typing of ALL, we studied 50 cases of denovo ALL t...

Histological examination of the bone marrow based on an evaluation of trephine biopsies is the gold standard for the diagnosis of bone marrow involvement in non-Hodgkin’s lymphomas while immunohistochemistry and molecular analysis may increase the accuracy and the sensitivity of lymphoma detection. Subtyping lymphomas on the trephine, according to the REAL classification, needs further investig...

Myelofibrosis (MF) is a rare disorder that classified as one of the myeloproliferative disorders. It BCR-ABL1- negative neoplasm characterized by abnormal proliferation hemopoietic stem cells within bone marrow, which leads to overproduction fibrous tissue. Our patient young girl 17 year old presented with lump in left upper abdomen, shortness breath & generalized swelling. The diagnosis wa...

Sonographic imaging of the brain was accomplished through a burr hole using a small, real-time, 5 MHz transducer in five patients. Brain tumors were accurately imaged, corresponding closely in morphology to the computed tomographic scan. Intraoperative sonography through a burr hole allows flexibility in technique and greatly facilitates brain biopsy procedures.