Time-resolved fluorescence (TRF) with a resolution higher than the periods of vibrations may provide the vibrational spectrum of an emitting species by directly recording the vibrational wave packet motions in time. We applied high-resolution TRF to investigate the excited-state dynamics of pigment yellow 101 (P.Y.101). The TRF spectra of P.Y.101 in dichloromethane showed that upon photoexcitat...

The histology and function of the kidney deteriorates with age and age-related diseases, but the mechanisms involved in renal aging are not known. In vitro studies suggest that telomere shortening is important in replicative senescence, and is accelerated by stresses that increase replication. This study explored the relationship between age and telomere length in surgical samples from 24 human...

Aging results in a loss of muscle mass and strength. Myoblasts play an important role in maintaining muscle mass through regenerative processes, which are impaired during aging. Vitamin E potentially ameliorates age-related phenotypes. Hence, this study aimed to determine the effects of the tocotrienol-rich fraction (TRF) and α-tocopherol (ATF) in protecting myoblasts from replicative senescenc...

The Flight Simulation and Software Branch (FSSB) at NASA Langley Research Center (LaRC) maintains the unique national asset identified as the Transport Research Facility (TRF). The TRF is a group of facilities and integration laboratories utilized to support the LaRC’s simulation-to-flight concept. This concept incorporates common software, hardware, and processes for both groundbased flight si...

It has been puzzling that mammalian telomeric proteins, including TRF1, TRF2, tankyrase, and TIN2 have no recognized orthologs in budding yeast. Here, we describe a human protein, hRap1, that is an ortholog of the yeast telomeric protein, scRap1p. hRap1 has three conserved sequence motifs in common with scRap1, is located at telomeres, and affects telomere length. However, while scRap1 binds te...

Résumé. Vingt-six truies en lactation ont reçu les traitements suivants : 1) solution saline physiologique ; 2) somatocrinine ou hGRF(1-29)NH 2(20 ¡lg.kg1) ; 3) thyréolibérine (TRF) (1 ¡lg.kg) ; 4) combinaison de GRF et de TRF (20 et 1 ¡lg.kgrespectivement). La solution saline ou les peptides ont été injectés par voie sous-cutanée, deux fois par jour, du 5e au 25e jour post-partum. Les niveaux ...

Circadian clocks orchestrate periods of rest or activity and feeding or fasting over the course of a 24-hour day and maintain homeostasis. To assess whether a consolidated 24-hour cycle of feeding and fasting can sustain health, we explored the effect of time-restricted feeding (TRF; food access limited to daytime 12 hours every day) on neural, peripheral, and cardiovascular physiology in Droso...

This paper describes aspects of a project aiming at creating a general, flexible and reusable software architecture to address planning problems in space missions. It introduces recent work to realize an open software framework for supporting development of planning and scheduling space applications. The framework, which is named TRF (Timeline-based Representation Framework), aims at supporting...

INTRODUCTION Skin aging may occur as a result of increased free radicals in the body. Vitamin E, the major chain-breaking antioxidant, prevents propagation of oxidative stress, especially in biological membranes. In this study, the molecular mechanism of tocotrienol-rich fraction (TRF) in preventing oxidative stress-induced skin aging was evaluated by determining the rate of total collagen synt...