نتایج جستجو برای: trf1
تعداد نتایج: 365 فیلتر نتایج به سال:
Protein kinase CK2 (formerly casein kinase II) is a tetrameric enzyme constitutively expressed in all eurakyotic tissues that plays a significant role in the regulation of cell proliferation, malignant transformation, and apoptosis. The catalytic alpha-subunit of the enzyme is known to exist in three isoforms CK2alpha, CK2alpha' and CK2alpha". CK2alpha" is highly expressed in liver compared wit...
Stabilization of telomere length in germline and highly proliferative human cells is required for long-term survival and for the immortal phenotype of cancer-derived cells. This is achieved through expression of telomerase reverse transcriptase (TERT), which synthesizes telomeric repeats through reverse transcription of its tightly associated RNA template (TR). The telomeric repeat binding fact...
The Rockefeller University Press $30.00 J. Cell Biol. Vol. 185 No. 5 827–839 www.jcb.org/cgi/doi/10.1083/jcb.200812121 JCB 827 Q. Zhu and L. Meng contributed equally to this work. Correspondence to Robert Y.L. Tsai: [email protected] Abbreviations used in this paper: ALT, alternative lengthening of telomeres; APB, ALT-associated PML body; coIP, coimmunoprecipitation; EMSA, electrophoretic mo...
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