PURPOSE To compare the relative plaque control efficacy of a marketed 0.454% stabilized stannous fluoride (SnF2) dentifrice relative to a triclosan/copolymer dentifrice using digital plaque imaging analysis (DPIA). METHODS This was a randomized, two-treatment, double-blind, parallel group design study that compared SnF2 and triclosan/copolymer dentifrices over a period of 3 weeks. DPIA was us...

Objective: Tooth hypersensitivity often starts in early adulthood because of gum recession and loss of the cementum covering dentin. The purpose of this study was to compare the effect of toothpaste,1 containing triclosan, potassium nitrate, zinc citrate,2 triclosan, potassium nitrate,3 calcium sodium phosphosilicate (novamin) on gingival health, plaque formation and dentin hypersensitivity in ...

Inhibition of FASN has emerged as a promising therapeutic target in cancer, and numerous inhibitors have been investigated. However, severe pharmacological limitations have challenged their clinical testing. The synthetic FASN inhibitor triclosan, which was initially developed as a topical antibacterial agent, is merely affected by these pharmacological limitations. Yet, little is known about i...

Exposure of the human food-borne pathogen Listeria monocytogenes to sublethal concentrations of triclosan can cause resistance to several aminoglycosides. Aminoglycoside-resistant isolates exhibit two colony morphologies: normal-size and pinpoint colonies. The purposes of the present study were to characterize the small colonies of L. monocytogenes and to determine if specific genetic changes c...

OBJECTIVES To study how disinfectants affect antimicrobial susceptibility and phenotype of Salmonella enterica serovar Typhimurium SL1,344. METHODS Wild-type strain SL1,344 and its isogenic gyrA mutant were passaged daily for 7 days in subinhibitory concentrations, and separately for 16 days in gradually increasing concentrations of a quaternary ammonium disinfectant containing formaldehyde a...

background: anti-microbial agents have been used as a chemotherapeutic agent to improve oral health. this in vitro study was carried out to determine antimicrobial efficacy of different toothpastes and mouthrinses against the oral pathogens.     methods: a total of five toothpastes and five mouthrinses were tested for their antimicrobial activity against three oral pathogens namely, streptococc...

Triclosan, a widely used biocide broadly found in aquatic environments, is cause of concern due to its unknown effects on non-targets organisms. In this study, multi biomarker approach was order evaluate the 72 h-effect triclosan freshwater alga Pseudokirchneriella subcapitata (Raphidocelis subcapitata). at environmental relevant concentrations (27 and 37 μg L−1), caused decrease proliferative ...

The effect of toxicants on the BOD degradation rate constant was used to quantitatively establish the toxicity of triclosan, phenol, and copper (II) against activated sludge microorganisms. Toxicities were tested over the following ranges of concentrations: 0-450 mg/L for phenol, 0-2 mg/L for triclosan, and 0-35 mg/L for copper sulfate (pentahydrate). According to the EC(50) values, triclosan w...