There is growing evidence that hypertriglyceridemia exacerbates ischemic injury. We tested the hypothesis that triglycerides impair myocardial recovery from low-flow ischemia in an ex vivo model and that such an effect is related to endothelin-1. Hyperglycemic (glucose concentration = 12 mmol/l) and hyperinsulinemic (insulin concentration = 1.2 micromol/l) isolated rat hearts were perfused with...

BACKGROUND In acute pancreatitis, oxygen free radicals (OFRs) and cytokines have been shown to play a role in the failure of pancreatic microcirculation and the development of local tissue damage. We studied the effects of trimetazidine (TMZ), a potent antioxidant and anti-ischemic agent, on acute pancreatitis. METHODS Rats were randomized into 3 groups: a control group (n = 15), a study grou...

BACKGROUND/AIM Renal oxidative stress occurs in ureteral obstructions. The purpose of this study was to investigate the effect of the antioxidant and antiischemic agent trimetazidine (TMZ) on oxidative stress following ureteral obstruction. MATERIALS AND METHODS Ten groups were established. Sham groups were checked as controls after 1 and 3 weeks. The other 8 groups had partial or complete ur...

The aim of this study was to develop and optimize Trimetazidine dihydrochloride (TM) controlled porosity osmotic pump (CPOP) tablets of directly compressed cores. A 2(3) full factorial design was used to study the influence of three factors namely: PEG400 (10% and 25% based on coating polymer weight), coating level (10% and 20% of tablet core weight) and hole diameter (0 "no hole" and 1 mm). Ot...

Összefoglaló. Bevezetés: A közelmúltban publikált ATPCI-vizsgálat azt eredményezte, hogy közvetlenül a sikeres revaszkularizáció után alkalmazott trimetazidin biztonságos volt, de nem volt effektívebb cardiovascularis halál, anginarekurrencia, cardialis hospitalizáció tekintetében, mint random kettős vakmódszerrel placebo. Célkitűzés: Az általunk korábban végzett ONECAPS nyitott, obszervációs v...

OBJECTIVES We sought to assess the effects of heparin and the potential protective effects of trimetazidine (TMZ) on exercise performance, plasma nitric oxide (NO), endothelin-1 (ET-1) and free fatty acid (FFA) release in patients with stable coronary artery disease (CAD). BACKGROUND Heparin has been shown to reduce the ischemic threshold in patients with CAD. Trimetazidine may affect myocard...

Metabolic therapy represents an innovative approach to the treatment of coronary artery disease and heart failure. The metabolic modulator, trimetazidine (Vastarel MR), offers particular positive effects in reducing the cell loss and reorganization that characterize the process of left ventricle remodeling, and is useful in improving ischemic or failed cell metabolism. Correction of the metabol...

Ischemic heart disease (IHD) patients with a decreased exercise capacity have increased angina attack rate and poor quality of life (QOL). Conventional hemodynamic drugs show limited improvement in exercise performance. Therefore we need new drugs that may further improve exercise capacity. Trimetazidine (TMZ) exerts its anti-ischemic effect by reducing fatty acid oxidation and stimulating gluc...

Acute coronary syndromes in diabetic patients often pose therapeutic challenges. Both percutaneous and surgical revascularization procedures have a lower success rate and a greater complication rate in diabetics compared to non diabetic patients. Here we discuss the case of an old diabetic patient with angina recurring 15 year after a CABG operation. Based on coronary anatomy and clinical prese...