In this study, we investigated intramolecular cyclizations in peptides containing quaternary amines. Two types of cyclization reactions are studied: (a) those involving a trimethylammonium butyric acid (TMAB) charge tag and (b) those involving trimethylated lysine. Both types of reactions result in the release of trimethylamine via an S(N)2 mechanism involving a lone pair of electrons on the ox...

Novel biohybrid homo-polyelectrolyte-based nanocarriers were formed by the complexation of insulin (INS) with a biocompatible and cationic polyelectrolyte, namely, poly(vinyl benzyl trimethylammonium chloride) (PVBTMAC). According to light-scattering techniques, hydrophilic PVBTMAC homo-polyelectrolyte forms single chains in aqueous media. The resulting PVBTMAC/INS via electrostatic co-assembly...

An alkali-hydrolysable surfactant, (1-tetradecyloxycarbonylmethyl)trimethylammonium chloride, was used as an emulsifier for emulsion polymerization of styrene in water. The polymerization yielded a high molecular-weight polymer almost quantitatively. Addition of a small amount of NaOH to the resulting latex solution precipitated the polymer immediately. Analysis of the centrifuged solid indicat...

We investigate the ability of a cationic comb polymer composed of a poly(trimethylammonium iodide ethyl methacrylate) (PTMAM) backbone and uncharged poly(ethylene glycol) (PEG) teeth to stabilize aqueous silica suspensions of varying ionic strength and pH. Both PTMAM-g-PEG and its homopolymer backbone, PTMAM, are synthesized via reversible addition-fragmentation chain transfer followed by quate...

Positively charged trimethylammonium-modified mixed monolayer protected clusters (MMPCs) interact with DNA by complementary electrostatic binding, serving as efficient DNA delivery systems. The stability of gold nanoparticle-bound DNA toward biological, physical, and chemical agents is investigated. The MMPC-bound DNA is efficiently protected from DNAse I digestion and experiences nicking/cleav...

Hexan-1 I: 6-bi(-trimethylammonium bromide) (C6) has been extensively studied about its pharmacological properties such as ganglionic blockade by Barlow, Ing, (1) (1948), Paton, Zaimis (2) (1951) and Wien, Mason (3) (1951) but less known about the mode of action in the biochemical sense. On the other hand it has been well known that nicotine action is antagonized by C6. The study of the effect ...

Silver (Ag) nanoparticles were successfully prepared by using the in-liquid pulsed plasma technique. This method is based on a low voltage, spark discharge in dielectric liquid. We explore effect of protecting ligands, specifically Cetyl Trimethylammonium Bromide (CTAB), Polyvinylpyrrolidone (PVP), and Sodium n-Dodecyl Sulphate (SDS), used as surfactant materials to prevent nanoparticle aggrega...

The monolithic materials of reduced graphene oxide (rGO) can be used successfully in CO2 adsorption. Here, the incorporation CeO2 particles with and without polymer brushes grafted from showed that structural properties could changed, affecting adsorption CO2. Polymer (1) poly(acrylic acid) (PAA), (2) poly(vinyl caprolactam) (PVCL) (3) poly[(2-(methacryloyloxy)ethyl) trimethylammonium chloride]...