Self-assembling peptide nanostructures have been shown to be of great importance in nature and presented many promising applications, for example, medicine as drug-delivery vehicles, biosensors, antivirals. Being very candidates the growing field bottom-up manufacture functional nanomaterials, previous work (Frederix, et al. 2011 2015) has screened all possible amino acid combinations di- tripe...

The 15N chemical shifts of eight aliphatic tripeptides have been measured at the natural-abundance level. For a given tripeptide, the resonances of the COOH-terminal and NH2-terminal amino acids can be identified by measurements at low or high pH. The shifts of the NH2-terminal amino acid nitrogens are essentially independent of the amino acids in the rest of the peptide. The shifts of the othe...

Among the products obtained upon the digestion of Achilles tendon collagen of cattle by the extracellular enzymes of Clostridium histolyticum are two peptides which give characteristic spots on paper chromatograms and seem to be present in significant quantities (1, 2). The isolation and identification of these peptides were undertaken in an effort to gain additional information regarding the a...

Library Generation Analysis and Combinatorial Chemistry: dedicated to Bruce Merrifield 1 Bruce Merrifield Dynamic Combinatorial Assembly of Peptide-Rhenium Coordinates: Application to the Selection of hCyp-18 inhibitors from a Library of 12 × 16 Components 3 Dynamic Combinatorial Assembly of Peptide-Rhenium Coordinates: Coordination Chemistry for Generating New Analogs of hCyp-18 Ligands 5 Oxor...

The conformational behaviour of delta Ala has been investigated by quantum mechanical method PCILO in the model dipeptide Ac-delta Ala-NHMe and in the model tripeptides Ac-X-delta Ala-NHMe with X = Gly, Ala, Val, Leu, Abu and Phe and is found to be quite different. The computational results suggest that in the model tripeptides the most stable conformation corresponds to phi 1 = -30 degrees, ps...