Downy thorn-apple Datura innoxia (Solanaceae) is an invasive plant species which can be introduced either accidentally or deliberately and have the ability to acclimatize in new environmental conditions. Scopolamine a natural alkaloid occur several species, including innoxia. Occurrence of all organs crucially important from viewpoint medical use, but also as risk toxicity for humans animals, t...

Tropinone is an alkamine intermediate at the branch point of biosynthetic pathways leading to various tropane alkaloids. Two stereospecifically distinct NADPH-dependent oxidoreductases, TR-I and TR-II, which, respectively, reduce tropinone to 3alpha-hydroxytropane (tropine) and 3beta-hydroxytropane (psi-tropine), were detected mainly in the root of tropane alkaloid-producing plants but not in n...

Background & Aim:A new sustainable tissue-based system is presented by plant hairy roots, preserving all of the several specialized types of cell with critical roles in allowing bioactive secondary molecules to be synthesized more consistently as usual. The system is also essential for studying the production of alkaloid in culture. Experimental: The ...

The (-)-hyoscyamine, atropine and scopolamine (hyoscine) are three valuable tropane alkaloids while scopolamine is the most important member of this group for the pharmaceutical industry due to its higher demand compared to hyoscyamine and atropine. Scopolamine is an anticholinergic reagent with several therapeutic applications. In the current study, the hairy roots culture of Daturametel was u...

agrobacterium rhizogenes (pri), a causative agent of hairy root disease, effectively induces hairy root formation in a variety of plant species. in our study four bacterial strains ar15834, a4, 9435 and c318 and three explants types leaf, stems and roots, were examined. hairy roots were induced from roots, stems and leaf explants. the highest transformation efficiency of 77% was achieved by usi...

Abstract Datura stramonium L. (Solanaceae) possesses a rich tropane alkaloids (TAs) spectrum. The plant contains, in particular, the allelopathic compounds scopolamine and atropine, which are poorly soluble water, thus limiting their use agrochemical formulations as biocidal deterrent agents against herbivore insects. efficacy of hydrophobic TAs extracts could be increased with improvement diss...

A 12 year old boy presented with an acute onset of anisocoria and blurred vision. Ocular motility was normal but his right pupil was dilated, round but sluggishly reactive to light. There was no history of trauma, eye drops' instillation, nebulised drugs or local ointments. His past medical history was negative.A third nerve palsy was considered but the performed cerebral MRI was normal.On furt...