BACKGROUND Trypanosomiasis is regarded as a constraint on livestock production in Western Kenya where the responsibility for tsetse and trypanosomiasis control has increasingly shifted from the state to the individual livestock owner. To assess the sustainability of these localised control efforts, this study investigates biological and management risk factors associated with trypanosome infect...

BACKGROUND & OBJECTIVES The Far-North region of Cameroon has been considered free of tsetse and trypanosomiasis for the past three decades. But recent reports by pastoralists indicate its reappearance in the region. This study was aimed to confirm the existence of cattle trypanosomiasis and determine its prevalence, and to establish pastoralists knowledge and practice (KP) of the disease in Ndi...

A field trial in Zimbabwe investigated the efficacy of insecticide-treated cattle as a barrier to prevent the re-invasion of tsetse, Glossina morsitans and G. pallidipes (Diptera: Glossinidae), into cleared areas. The original tsetse barrier consisted of insecticide-treated odour-baited targets, at an operational density of four to five targets per km2, supported by insecticide-treatments of ca...

OBJECTIVES To detail clinical and polysomnographic characteristics in patients affected with Trypanosoma brucei gambiense (Tb.g.) human African trypanosomiasis (HAT) at different stages of evolution and to measure and compare cerebrospinal fluid (CSF) levels of hypocretin-1 with narcoleptic patients and neurologic controls. METHODS Twenty-five untreated patients affected with T.b.g. HAT were ...

An estimated 10 million people are infected with Trypanosoma cruzi (the parasite that causes Chagas disease) worldwide, mostly in Latin America. Chagas disease was once entirely confined to the Region of the Americas – principally Latin America – but it has now spread to other continents. Chagas disease is curable if treatment is initiated soon after infection. Up to 30% of chronically infected...

Mice infected with the protozoan parasite Trypanosoma brucei brucei and treated subcuratively with the trypanocidal drug diminazene aceturate develop an acute inflammatory meningoencephalitis with associated astrocytic proliferation. This reaction is very similar to that seen in the fatal posttreatment reactive encephalopathies that can occur in human African trypanosomiasis. The 11-amino acid ...

Quantitative and qualitative techniques for assessment of the intrathecal humoral immune response in human African trypanosomiasis were compared, and their diagnostic potential for detection of the meningo-encephalitic stage of the disease was evaluated. Total and trypanosome specific immunoglobulin G (IgG) and IgM intrathecal synthesis were studied in paired cerebrospinal fluid (CSF) and blood...

Wild animals, pets, zoo animals and mammals of veterinary importance heavily suffer from trypanosomiasis 1 . Drugs with serious side effects are currently mainstay of therapies used by veterinarians. Trypanosomiasis is caused by Trypanosoma sp. leading to sleeping sickness in humans. Surface modified (hydrophobic and lipophilic) amorphous nanoporous silica molecules could be effectively used as...

Trypanosomiasis remains a major constraint to the development of livestock in Sub-Saharan Africa and a big part of Africa is rendered unsuitable for the production of livestock due to the presence of tsetse flies. A cross sectional study was conducted to estimate the prevalence of trypanosomosis in Mulanda Sub County, Tororo district in Eastern Uganda during the month of April 2014. Whole blood...