dear editor-in-chief we read with interest the study by khazaei et al. (1) in which the authors have nicely concluded that pcr is more sensitive test than ziehl-neelsen staining and histo-pathological examination for the diagnosis of tuberculosis (tb). they have rightly pointed to use pcr, selectively, in acidfast bacilli negative paucibacillary forms of tb. however, we intend to highlight few ...

Two new drugs-bedaquiline and delamanid-have recently been approved by stringent regulatory authorities to treat multidrug-resistant tuberculosis (TB) and recommended by the World Health Organization for use under defined programmatic conditions. Introducing the medications in TB programs worldwide has not kept pace with the need for these drugs. In response, the DR-TB STAT (Drug-Resistant TB S...

Researchers may believe – and patients and physicians may hope – that a particular treatment (perhaps because it is new) is better than other available treatments; but it may often turn out to be worse. When the British Medical Research Council’s controlled trial of streptomycin for pulmonary tuberculosis was conceived in 1946, none of the therapies used to treat the disease had been shown in c...

background: lower lung field tuberculosis is atypical presentation of pulmonary tuberculosis which often causes confusion in diagnosis. hiv/aids epidemic has considerably increased its incidence. this study was designed to identify the prevalence and different clinical conditions of lung tuberculosis in conjunction with its common clinical and radiological presentations and its treatment.   met...

Tuberculosis is a vagarious infectious disease that generally affects the lungs. Accordingly, in some cases, it can also affect the liver and kidney. Host genetic may affect tuberculosis caused by bacillus Mycobacterium tuberculosis. The main risk factors for the disease are a weakened immune system because of diabetes, some cancers, HIV/AIDS, severe kidney disease, cancer treatment, a...

The objective : to evaluate immediate and postponed efficacy of MDR TB patients' treatment with short-course chemotherapy regimens. Subjects Methods . Efficacy safety were evaluated in 42 patients. Results 36 (85,7%) patients completed successfully, 1 (2,4%) patient died non-tuberculosis, 5 (11,9%) defaulted from treatment. There no such outcomes as failure TB. Over the 4-year follow-up period ...

BACKGROUND Tuberculosis during pregnancy and treatment outcomes are poorly defined in high prevalence tuberculosis and HIV settings. METHODS A prospective cohort study of pregnant and postpartum women identified to be routinely on antituberculosis treatment was conducted at Tygerberg Hospital, Cape Town, South Africa, from January 2011 through December 2011. Maternal tuberculosis disease spec...

Background Information. Monitoring outcome of tuberculosis treatment and understanding the specific reasons for unsuccessful treatment outcome are important in evaluating the effectiveness of tuberculosis control program. This study investigated tuberculosis treatment outcomes and predictors for unsuccessful treatment outcome in Ogbomoso town, Southwestern Nigeria. Methodology. Medical records ...

BACKGROUND There is growing concern that interferon-γ release assays (IGRAs) are being used off-label for the diagnosis of active tuberculosis (TB) disease in many high-burden settings, including India, where the background prevalence of latent TB infection is high. We analyzed the costs and consequences of using IGRAs for the diagnosis of active TB in India from the perspective of the Indian T...

We describe 27 children and adolescents <18 years of age who received bedaquiline during treatment for multidrug-resistant tuberculosis. We report good treatment responses and no cessation attributable to adverse effects. Bedaquiline could be considered for use with this age group for multidrug-resistant tuberculosis when treatment options are limited.