OBJECTIVES To review the protective efficacy of the first and second doses of BCG vaccine and to assess its major indications and contraindications. SOURCES OF DATA A systematic review of the literature was made by searching PubMed and selecting studies carried out in the last 50 years. The studies were grouped according to their design (clinical trials, case-control studies, and meta-analyse...

Copyright © 2015 Vishwanath Venketaraman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Mycobacterium tuberculosis (M. tuberculosis), the causative agent for tuberculosis (TB), is responsible for 1.5 million deaths and 9 m...

Tuberculosis (TB), a major public health problem, is a re-emerging challenging through the world. Prevention of this disease is a priority of WHO. Many subunit vaccine have been candidate for vaccination. Evaluating the safety and efficacy of these antigens is the concern of many researchers. This review is discussed efficiency or non-efficiency of CFP-10antigen with Fcγ2α IgG for vaccine desig...

introduction: infections by multidrug resistant mycobacterium tuberculosis (mdr-tb) is a major public health challenge. secretion of proteins by m. tuberculosis plays an important role in the pathogenesis of the bacterium. we compared the protein profiles of susceptible m. tuberculosis and mdr-tb isolates using proteomic analyses, namely two dimensional gel electrophoresis (2de) and mass spectr...

Tuberculosis (TB) is an infectious disease caused mainly by the bacillus Mycobacterium tuberculosis. The World Health Organization estimates that 8.6 million new TB cases occurred in 2012, resulting in 1.3 million deaths [1]. TB is the second leading cause of death caused by an infectious disease worldwide after immunodeficiency virus (HIV). Despite the availability of an effective chemotherapy...

objective(s) tuberculosis (tb) is the leading cause of mortality among the infectious diseases, especially in developing countries. one of the main goals in tuberculosis research is to identify antigens which have the ability of inducing cellular and/or humoral immunity in order to use them in diagnostic reagents or vaccine design. the aim of this study was to clone and express the tb'0.4 ...

Three-quarters of a century after the introduction of Mycobacterium bovis BCG, the first tuberculosis vaccine, new vaccines for tuberculosis are finally entering clinical trials. This breakthrough is based not only on advances in proteomics and genomics which have made the construction of new vaccines possible, but also on a greatly expanded knowledge of the immunology of tuberculosis. Here we ...

972 www.thelancet.com Vol 381 March 23, 2013 One of the great quests of contemporary medical research is the search for an improved tuberculosis vaccine—one that provides greater and more consistent protection against tuberculosis than the BCG vaccine can achieve. The stakes are high. The venture is costly and risky, but has a huge potential payoff . A high-effi cacy vaccine could revolutionise...